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首页> 外文会议>Optical Coherence tomography and coherence domain optical methods in biomedicine XX >Development of a new, robust and accurate, spectroscopic metric for scatterer size estimation in Optical Coherence Tomography (OCT) images
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Development of a new, robust and accurate, spectroscopic metric for scatterer size estimation in Optical Coherence Tomography (OCT) images

机译：开发一种新的，健壮且准确的光谱学度量标准，用于光学相干断层扫描（OCT）图像中的散射体大小估计

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摘要

The modulations appearing on the backscattering spectrum originating from a scatterer are related to its diameter as described by Mie theory for spherical particles. Many metrics for Spectroscopic Optical Coherence Tomography (SOCT) take advantage of this observation in order to enhance the contrast of Optical Coherence Tomography (OCT) images. However, none of these metrics has achieved high accuracy when calculating the scatterer size, In this work, Mie theory was used to further investigate the relationship between the degree of modulation in the spectrum and the scatterer size. From this study, a new spectroscopic metric, the bandwidth of the Correlation of the Derivative (COD) was developed which is more robust and accurate, compared to previously reported techniques, in the estimation of scatterer size. The self-normalizing nature of the derivative and the robustness of the first minimum of the correlation as a measure of its width, offer significant advantages over other spectral analysis approaches especially for scatterer sizes above 3 μm. The feasibility of this technique was demonstrated using phantom samples containing 6,10 and 16 μm diameter microspheres as well as images of normal and cancerous human colon. The results are very promising, suggesting that the proposed metric could be implemented in OCT spectral analysis for measuring nuclear size distribution in biological tissues. A technique providing such information would be of great clinical significance since it would allow the detection of nuclear enlargement at the earliest stages of precancerous development.
机译：如球形粒子的米氏理论所述，出现在源自散射体的反向散射光谱上的调制与其直径有关。光谱光学相干断层扫描（SOCT）的许多指标都利用了这一观察结果，以增强光学相干断层扫描（OCT）图像的对比度。但是，这些指标在计算散射体尺寸时都没有达到很高的精度。在这项工作中，使用Mie理论进一步研究了光谱中调制度与散射体尺寸之间的关系。根据这项研究，开发了一种新的光谱度量标准，即导数相关性（COD）的带宽，与以前报道的技术相比，它在估计散射体大小方面更加可靠和准确。导数的自归一化性质和相关关系的第一个最小值的稳健性（作为度量其宽度的度量），相对于其他光谱分析方法（尤其是对于大于3μm的散射体），具有明显的优势。使用包含6,10和16μm直径微球的幻影样品以及正常和癌性人类结肠的图像证明了该技术的可行性。结果是非常有希望的，表明可以在OCT光谱分析中实施所提出的度量标准，以测量生物组织中的核尺寸分布。提供这种信息的技术将具有重大的临床意义，因为它将允许在癌前发展的最早阶段检测到核增大。

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  • 会议地点 San Francisco CA(US)
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    Michalis Kassinopoulos; Costas Pitris;

  • 作者单位

    KIOS Research Center for Intelligent System and Networks, Dept. of Electrical and Computer Engineering, University of Cyprus, 75 Kallipoleos St, Nicosia, Cyprus, 1678;

    KIOS Research Center for Intelligent System and Networks, Dept. of Electrical and Computer Engineering, University of Cyprus, 75 Kallipoleos St, Nicosia, Cyprus, 1678;

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