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Point-of-care Optical Tool to Detect Early Stage of Hemorrhage and Shock

机译:现场护理光学工具,可检测出血和休克的早期阶段

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There is a critical unmet clinical need for a device that can monitor and predict the onset of shock: hemorrhagic shock or bleeding to death, septic shock or systemic infection, and cardiogenic shock or blood flow and tissue oxygenation impairment due to heart attack. Together these represent 141 M patients per year. We have developed a monitor for shock based on measuring blood flow in peripheral (skin) capillary beds using diffuse correlation spectroscopy, a form of dynamic light scattering, and have demonstrated proof-of-principle both in pigs and humans. Our results show that skin blood flow measurement, either alone or in conjunction with other hemodynamic properties such as heart rate variability, pulse pressure variability, and tissue oxygenation, can meet this unmet need in a small self-contained patch-like device in conjunction with a hand-held processing unit. In this paper we describe and discuss the experimental work and the multivariate statistical analysis performed to demonstrate proof-of-principle of the concept.
机译:临床上迫切需要一种能够监测和预测休克发作的设备:出血性休克或死亡致死,败血性休克或全身感染,以及因心脏病发作而导致的心源性休克或血流和组织氧合障碍。这些一起代表每年1.41亿患者。我们已经开发出一种用于监测休克的监视器,该监视器基于使用扩散相关光谱法(一种动态光散射形式)测量外周(皮肤)毛细血管床中的血流量,并且已经证明了猪和人的原理证明。我们的结果表明,单独或与其他血液动力学特性(如心率变异性,脉搏压力变异性和组织氧合)结合使用的皮肤血流量测量,可以在小型自备贴片状设备中结合使用来满足这种未满足的需求。手持式处理单元。在本文中,我们描述并讨论了实验工作和进行的多元统计分析,以证明该概念的原理性证明。

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