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首页> 外文会议>Optical Elastography and Tissue Biomechanics II >Quantitative shear wave optical coherence elastography (SW-OCE) with acoustic radiation force impulses (ARFI) induced by phase array transducer
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Quantitative shear wave optical coherence elastography (SW-OCE) with acoustic radiation force impulses (ARFI) induced by phase array transducer

机译：相阵列换能器诱发的具有声辐射力脉冲（ARFI）的定量剪切波光学相干弹性成像（SW-OCE）

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摘要

Shear Wave Optical Coherence Elastography (SW-OCE) uses the speed of propagating shear waves to provide a quantitative measurement of localized shear modulus, making it a valuable technique for the elasticity characterization of tissues such as skin and ocular tissue. One of the main challenges in shear wave elastography is to induce a reliable source of shear wave; most of nowadays techniques use external vibrators which have several drawbacks such as limited wave propagation range and/or difficulties in non-invasive scans requiring precisions, accuracy. Thus, we propose linear phase array ultrasound transducer as a remote wave source, combined with the high-speed, 47,000-frame-per-second Shear-wave visualization provided by phase-sensitive OCT. In this study, we observed for the first time shear waves induced by a 128 element linear array ultrasound imaging transducer, while the ultrasound and OCT images (within the OCE detection range) were triggered simultaneously. Acoustic radiation force impulses are induced by emitting 10 MHz tone-bursts of sub-millisecond durations (between 50 μm - 100 μm). Ultrasound beam steering is achieved by programming appropriate phase delay, covering a lateral range of 10 mm and full OCT axial (depth) range in the imaging sample. Tissue-mimicking phantoms with agarose concentration of 0.5% and 1% was used in the SW-OCE measurements as the only imaging samples. The results shows extensive improvements over the range of SW-OCE elasticity map; such improvements can also be seen over Shear-wave Velocities in softer and stiffer phantoms, as well as determining the boundary of multiple inclusions with different stiffness. This approach opens up the feasibility to combine medical ultrasound imaging and SW-OCE for high-resolution localized quantitative measurement of tissue biomechanical property.
机译：剪切波光学相干弹性成像（SW-OCE）利用传播的剪切波的速度来定量测量局部剪切模量，使其成为表征皮肤和眼组织等组织弹性的有价值的技术。剪切波弹性成像的主要挑战之一是要产生可靠的剪切波源。当今大多数技术使用外部振动器，这些振动器具有一些缺点，例如有限的波传播范围和/或在需要精确度，准确性的非侵入式扫描中存在困难。因此，我们提出将线性相控阵超声换能器作为远程波源，并结合相敏OCT提供的高速，每秒47,000帧的剪切波可视化功能。在这项研究中，我们首次观察到由128元素线性阵列超声成像换能器引起的剪切波，而超声和OCT图像（在OCE检测范围内）同时被触发。通过发出亚毫秒级持续时间（介于50μm-100μm之间）的10 MHz音突发，可以引起声辐射力脉冲。通过编程适当的相位延迟，可以实现超声波束控制，该相位延迟覆盖了10 mm的横向范围和成像样本中的整个OCT轴向（深度）范围。在SW-OCE测量中使用琼脂糖浓度分别为0.5％和1％的组织模拟体模作为唯一的成像样品。结果表明，在SW-OCE弹性图的范围内有广泛的改进；在较软和较硬的模型中，也可以在剪切波速度上看到这种改进，并确定具有不同刚度的多个夹杂物的边界。这种方法为将医学超声成像和SW-OCE结合起来用于组织生物力学特性的高分辨率局部定量测量提供了可能性。

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  • 来源
    《Optical Elastography and Tissue Biomechanics II》|2015年|93270U.1-93270U.5|共5页
  • 会议地点 San Francisco CA(US)
  • 作者

    Shaozhen Song; Mian Minh Le; Ruikang K. Wang; Zhihong Huang;

  • 作者单位

    School of Engineering, Physics and Mathematics, University of Dundee, Dundee, UK DD1 4HN,Dept. of Bioengineering, University of Washington, Seattle, WA, USA 98195;

    School of Engineering, Physics and Mathematics, University of Dundee, Dundee, UK DD1 4HN;

    Dept. of Bioengineering, University of Washington, Seattle, WA, USA 98195,Department of Ophthalmology, University of Washington, 325 9th Avenue, Seattle, Washington, USA 98104;

    School of Engineering, Physics and Mathematics, University of Dundee, Dundee, UK DD1 4HN;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Shear wave imaging; acoustic radiation force impulse; optical coherence elastography;

    机译：剪切波成像；声辐射力脉冲光学相干弹性成像;

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