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首页> 外文会议>Optical Elastography and Tissue Biomechanics II >Assessment of the biomechanical properties of porcine cornea after UV cross-linking at different intraocular pressures
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Assessment of the biomechanical properties of porcine cornea after UV cross-linking at different intraocular pressures

机译：不同眼压下紫外线交联后猪角膜的生物力学性能评估

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摘要

In this study we demonstrate the use of phase-stabilized swept-source optical coherence elastography (PhS-SSOCE) to assess the biomechanical properties of porcine corneas before and after collagen cross-linking (CXL) at different intraocular pressures by measuring the velocity of an air-pulse induced elastic wave and recovery process rate of an air-pulse induced deformation. Young's moduli were estimated by two different methods: the shear wave equation and a newly developed elasticity reconstruction model. The results show that the corneas became stiffer after the CXL treatment, as evidenced by the increased elastic wave velocity and recovery process rate and greater Young's modulus. This non-contact and noninvasive measurement technique utilizes minimal force for excitation (deformation less than 10 urn in amplitude) of the tissue. Thus, it can be potentially used to study the biomechanical properties of ocular and other delicate tissues.
机译：在这项研究中，我们证明了使用相稳定的扫频光学相干弹性成像（PhS-SSOCE）通过测量眼压的速度来评估猪角膜在不同眼压下胶原交联之前和之后的生物力学特性。空气脉冲引起的弹性波和空气脉冲引起的变形的恢复过程速率。杨氏模量通过两种不同的方法估算：剪切波方程和新开发的弹性重建模型。结果表明，CXL处理后角膜变硬，这可以通过增加弹性波速度和恢复过程速率以及更大的杨氏模量来证明。这种非接触式和非侵入性的测量技术利用最小的力来激发组织（振幅小于10 um的变形）。因此，它可以潜在地用于研究眼和其他脆弱组织的生物力学特性。

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  • 来源
    《Optical Elastography and Tissue Biomechanics II》|2015年|93270Z.1-93270Z.6|共6页
  • 会议地点 San Francisco CA(US)
  • 作者

    Jiasong Li; Manmohan Singh; Srilatha Vantipalli; Zhaolong Han; Chih-hao Liu; Michael D. Twa; Kirill V. Larin;

  • 作者单位

    Department of Biomedical Engineering, University of Houston, 4800 Calhoun Rd, Houston, TX, 77004;

    Department of Biomedical Engineering, University of Houston, 4800 Calhoun Rd, Houston, TX, 77004;

    Departmen of Optometry, University of Houston, 4800 Calhoun Rd, Houston, TX, 77004;

    Department of Biomedical Engineering, University of Houston, 4800 Calhoun Rd, Houston, TX, 77004;

    Department of Biomedical Engineering, University of Houston, 4800 Calhoun Rd, Houston, TX, 77004;

    School of Optometry, University of Alabama at Birmingham, HPB 121, 1720 2nd Avenue South Birmingham, AL 35294;

    Department of Biomedical Engineering, University of Houston, 4800 Calhoun Rd, Houston, TX, 77004,Department of Molecular Physiology and Biophysics, Baylor College of Medicine. One Baylor Plaza, Houston, TX 77030;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    OCE; OCT; elastic wave; air-pulse; Young's modulus; CXL; biomedical property; noninvasive;

    机译：OCE;华侨城;弹性波空气脉冲杨氏模量CXL；生物医学特性；无创;

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