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首页> 外文会议>Optical fibers, sensors, and devices for biomedical diagnostics and treatment XI >Delivery of single-mode and multi-mode therapeutic laser light using a single and dual cladding optical fiber for a scanning fiberendoscope
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Delivery of single-mode and multi-mode therapeutic laser light using a single and dual cladding optical fiber for a scanning fiberendoscope

机译：使用用于扫描光纤内窥镜的单包层和双包层光纤传输单模和多模治疗激光

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摘要

The integration of thermal and photodynamic therapy into a scanning fiber endoscope (SFE) for the purpose of pixel accurate laser therapy during an endoscopic procedure has been examined using two distinct methods: combining R-635nm, G-532nm, B-440nm (RGB) laser light for imaging with high-power 405nm single-mode or multi-mode laser light for therapy. The single-mode system utilizes a SIFAM 405/635nm fused fiber device to combine single-mode 405nm and 635nm laser light into the core of a single output fiber. The multi-mode system uses a custom combiner (Lightel Technologies) to guide single-mode RGB light from one fiber into the core of a custom single-mode dual cladding fiber (DCF, Coherent) and places multi-mode 405nm light from a second input optical fiber into the inner cladding of the DCF. This multi-mode system has a higher output power measured at 300mW compared to the single-mode system measured at 30mW before the addition of combiners. A lens system from the SFE at the distal tip of each therapeutic system was used to focus the light without scanning. The resulting minimum spot diameters were 77microns for the single-mode system and 311 microns for the multi-mode system, which equates to fluence rates of 644W/cm2 and 395W/cm2 respectively. Future studies will integrate a scanning fiber probe to the outputs of each system allowing the therapeutic light to be directed throughout an entire image as well as the ability to use wide-field fluorescence imaging with 405nm excitation.
机译：已使用两种不同的方法检查了将热和光动力疗法集成到扫描纤维内窥镜（SFE）中以在内窥镜检查过程中实现像素精确激光疗法的目的：结合使用R-635nm，G-532nm，B-440nm（RGB）用于治疗的405nm单模或多模大功率激光成像。单模系统利用SIFAM 405 / 635nm融合光纤设备将单模405nm和635nm激光组合到单输出光纤的纤芯中。多模系统使用定制的组合器（Lightel Technologies）将来自一根光纤的单模RGB光引导到定制的单模双包层光纤（DCF，相干）的芯中，并从第二根光纤发出405nm多模光。将光纤输入DCF的内包层。与添加合并器之前的30mW的单模系统相比，该多模系统的300mW的输出功率更高。来自每个治疗系统远端的SFE的透镜系统用于聚焦光而无需扫描。单模系统的最小光斑直径为77微米，多模系统的最小光斑直径为311微米，分别相当于644W / cm2和395W / cm2的通量率。未来的研究将把扫描光纤探头集成到每个系统的输出中，从而使治疗光可以定向到整个图像上，并具有使用405nm激发的宽视场荧光成像的能力。

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