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Bowel perforation detection using metabolic fluorescent chlorophylls

机译：使用代谢性荧光叶绿素检测肠穿孔

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Thus far, there have been tries of detection of disease using fluorescent materials. We introduce the chlorophyll derivatives from food plants, which have longer-wavelength emissions (at ＞650 nm) than those of fluorescence of tissues and organs, for detection of bowel perforation. To figure out the possibility of fluorescence spectroscopy as a monitoring sensor of bowel perforation, fluorescence from organs of rodent models, intestinal and peritoneal fluids of rodent models and human were analyzed. In IVIS fluorescence image of rodent abdominal organ, visualization of perforated area only was possible when threshold of image is extremely finely controlled. Generally, both perforated area of bowel and normal bowel which filled with large amount of chlorophyll derivatives were visualized with fluorescence. The fluorescence from chlorophyll derivatives penetrated through the normal bowel wall makes difficult to distinguish perforation area from normal bowel with direct visualization of fluorescence. However, intestinal fluids containing chlorophyll derivatives from food contents can leak from perforation sites in situation of bowel perforation. It may show brighter and longer-wavelength regime emissions of chlorophyll derivatives than those of pure peritoneal fluid or bio-organs. Peritoneal fluid mixed with intestinal fluids show much brighter emissions in longer wavelength (at＞650 nm) than those of pure peritoneal fluid. In addition, irrigation fluid, which is used for the cleansing of organ and peritoneal cavity, made of mixed intestinal and peritoneal fluid diluted with physiologic saline also can be monitored bowel perforation during surgery.
机译：迄今为止，已经尝试使用荧光材料检测疾病。我们引入了食用植物的叶绿素衍生物，用于检测肠穿孔，该叶绿素衍生物具有比组织和器官的荧光更长的波长发射（＞ 650 nm）。为了确定荧光光谱作为肠穿孔监测传感器的可能性，分析了来自啮齿动物模型的器官，啮齿动物模型的肠和腹膜液以及人类的荧光。在啮齿动物腹腔器官的IVIS荧光图像中，只有在非常精细地控制图像阈值的情况下，才可能显示穿孔区域。通常，用荧光观察肠和正常肠的充满大量叶绿素衍生物的穿孔区域。来自叶绿素衍生物的荧光穿透正常肠壁，使得难以通过直接可视化荧光来区分穿孔区域与正常肠。然而，在肠穿孔的情况下，含有来自食物成分的叶绿素衍生物的肠液会从穿孔部位泄漏。与纯腹膜液或生物器官相比，它可能显示出叶绿素衍生物更亮和更长波长的发射。与纯腹膜液相比，与肠液混合的腹膜液在更长的波长（＞ 650 nm）处显示出更亮的发射。此外，还可以在手术过程中监测用于冲洗器官和腹膜腔的冲洗液，这些冲洗液是由用生理盐水稀释的肠液和腹膜液混合而成的。

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