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首页> 外文会议>Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications VI; Progress in Biomedical Optics and Imaging; vol.7 no.6 >The CritiView - A new fiber optic based optical device for the assessment of tissue vitality
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The CritiView - A new fiber optic based optical device for the assessment of tissue vitality

机译：CritiView-一种新的基于光纤的光学装置，用于评估组织活力

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The most important parameter that reflects the balance between oxygen supply and demand in tissues is the mitochondrial NADH redox state that could be monitored In vivo. Nevertheless single parameter monitoring is limited in the interpretation capacity of the very complicated pathophysiological events, therefore three more parameters were added to the NADH and the multiparametric monitoring system was used in experimental and clinical studies. In our previous paper we described the CritiView (CRV1) including a fiber optic probe that monitor four physiological parameters in real time. In the new model (CRV3) several factors such as UV safety, size and price of the device were improved significantly. The CRV3 enable to monitor the various parameters in three different locations in the tissue thus increasing the reliability of the data due to the better statistics. The connection between the device and the monitored tissue could be done by various types of probes. The main probe that was tested also in clinical studies was a special 3 points probe that includes 9 optical fibers (3 in each point) that was embedded in a three way Foley catheter. This catheter enabled the monitoring of urethral wall vitality as an indicator of the development of body metabolic emergency state. The three point probe was tested in the brain exposed to the lack of oxygen (Anoxia, Hypoxia or Ischemia). A decrease in blood oxygenation and a large increase in mitochondrial NADH fluorescence were recorded. The microcirculatory blood flow increased during anoxia and hypoxia and decreased significantly under ischemia.
机译：反映组织供氧之间需求平衡的最重要参数是可在体内监测的线粒体NADH氧化还原状态。然而，单参数监测在非常复杂的病理生理事件的解释能力上受到限制，因此，将另外三个参数添加到NADH中，并将多参数监测系统用于实验和临床研究。在我们之前的论文中，我们描述了CritiView（CRV1），其中包括一个可实时监控四个生理参数的光纤探头。在新型号（CRV3）中，紫外线安全性，设备尺寸和价格等几个因素得到了显着改善。 CRV3能够监视组织中三个不同位置的各种参数，从而由于具有更好的统计信息而提高了数据的可靠性。设备和被监测组织之间的连接可以通过各种类型的探针来完成。在临床研究中也测试过的主要探针是特殊的3点探针，其中包括9根光纤（每个点3根），并嵌入三通Foley导管中。该导管能够监测尿道壁活力，作为机体代谢紧急状态发展的指标。在暴露于缺氧（缺氧，缺氧或缺血）的大脑中测试了三点探针。记录到血液氧合减少和线粒体NADH荧光大量增加。在缺氧和缺氧时微循环血流量增加，在缺血下微循环血流量明显减少。

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