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首页> 外文会议>Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications VI; Progress in Biomedical Optics and Imaging; vol.7 no.6 >Bio-sensing: The use of a novel sensitive optical detector
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Bio-sensing: The use of a novel sensitive optical detector

机译：生物传感：使用新型灵敏的光学探测器

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摘要

Recent advances in bio-optical methods for Medical Diagnostics, Optical Biopsy and Non-Invasive Imaging have the potential to prolong and improve the quality of life while significantly reducing medical costs for the diagnosis and tracking of diseases. Advances in the Genomics and pharmaceutical discovery using micro-array technology and High Throughput Screening permit to study thousands of compounds in short periods of time. This paper presents a new Si-based photonic sensors and sensor arrays with internal discrete amplification that offers the necessary qualities thus allowing development of a new generation of high gain, ultra low noise, universal analog and counting photodetectors for bio-optical sensing applications. The new photodetectors can operate in the linear detection mode with a gain-bandwidth product of up to 10~(15)/sec and in the photon counting mode with count rates of up to 10~9 counts/sec. Detectors based on this amplification mechanism could have performance parameters superior to those of conventional avalanche photodiodes and photomultiplier tubes. For tested silicon photodetector prototypes, measured excess noise factor is as low as 1.02 at gains greater than 100,000.
机译：用于医学诊断，光学活检和非侵入性成像的生物光学方法的最新进展具有延长和改善生活质量的潜力，同时大大降低了诊断和跟踪疾病的医疗成本。使用微阵列技术和高通量筛选技术在基因组学和药物发现方面的进展允许在短时间内研究成千上万种化合物。本文介绍了一种新型的基于Si的光子传感器和具有内部离散放大功能的传感器阵列，它们提供了必要的质量，从而允许开发用于生物光学传感应用的新一代高增益，超低噪声，通用模拟和计数光电探测器。新的光电探测器可以在线性检测模式下以高达10〜（15）/ sec的增益带宽乘积工作，并且可以在光子计数模式下以高达10〜9个计数/秒的计数率工作。基于这种放大机制的检测器可能具有优于常规雪崩光电二极管和光电倍增管的性能参数。对于经过测试的硅光电探测器原型，当增益大于100,000时，测得的多余噪声因子低至1.02。

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