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A hybrid system for intraocular pressure measurements through combining a capacitive flexible force sensor and swept-source optical coherence tomography

机译:通过组合电容性柔性力传感器和扫频光学相干断层扫描技术进行眼压测量的混合系统

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摘要

Intraocular pressure (IOP) is the pressure exerted by the eye contents on the eyeball wall and is used to maintain the shape of the eyeball. It may cause glaucoma when the dynamic balance of the generation and excretion of aqueous humor in the eyeball is broken. The Goldmann applanation tonometer (GAT) based on the Imbert-Fick principle is considered to be the reference standard for glaucoma diagnosis in clinics. OCT is widely used for eye screening by imaging structural changes caused by various eye diseases. In this paper, we have developed an OCT-assisted transparent flexible force sensing system (O-FPSS) for IOP measurements. In general, the hybrid O-FPSS consists of a droplet-based flexible transparent force sensor placed over an optical coherence tomography imaging lens, in which the IOP is measured once the apex of the cornea is flatted by the sensor. According to the Imbert-Fick law, when the cornea is flattened, the pressure applied by the sensor equals to the IOP. Specially, the droplet-based capacitive flexible force sensor is consisted by two flexible conductive membranes, and an ionic droplet is sandwiched in between, in which the force applied on the cornea can be monitored by the capacitance output. The sensing membrane deforms uniformly upon contacting the cornea, leading to the expansion of the droplet and an increase of the overall capacitance. On the other hand, to get the flatten area between the sensor and the cornea, a swept-source OCT (SS-OCT) is used to record the interfacial image with a resolution of 5μm.
机译:眼内压(IOP)是眼睛内容物在眼球壁上施加的压力,用于维持眼球的形状。眼球房水的产生和排泄的动态平衡被破坏时,可能会引起青光眼。基于Imbert-Fick原理的Goldmann压平眼压计(GAT)被认为是临床青光眼诊断的参考标准。 OCT通过对由各种眼疾引起的结构变化进行成像来广泛用于眼科筛查。在本文中,我们开发了一种用于IOP测量的OCT辅助透明柔性力传感系统(O-FPSS)。通常,混合型O-FPSS由基于液滴的柔性透明力传感器组成,该传感器位于光学相干断层扫描成像镜头上,一旦角膜的顶点被传感器压平,便会测量IOP。根据Imbert-Fick法则,当角膜展平时,传感器施加的压力等于IOP。特别地,基于液滴的电容式柔性力传感器由两个柔性导电膜组成,离子液滴夹在其间,其中的角膜上的力可以通过电容输出来监控。传感膜在接触角膜时会均匀变形,从而导致液滴膨胀并增加总电容。另一方面,为了获得传感器和角膜之间的平坦区域,使用扫频OCT(SS-OCT)记录分辨率为5μm的界面图像。

著录项

  • 来源
    《Advanced optical imaging technologies》|2018年|108161Q.1-108161Q.8|共8页
  • 会议地点 Beijing(CN)
  • 作者单位

    School of Electronic and Information Engineering, Soochow University, Suzhou, Jiangsu 215006, China;

    School of Electronic and Information Engineering, Soochow University, Suzhou, Jiangsu 215006, China;

    School of Electronic and Information Engineering, Soochow University, Suzhou, Jiangsu 215006, China;

    School of Electronic and Information Engineering, Soochow University, Suzhou, Jiangsu 215006, China;

    School of Electronic and Information Engineering, Soochow University, Suzhou, Jiangsu 215006, China;

    School of Electronic and Information Engineering, Soochow University, Suzhou, Jiangsu 215006, China;

    School of Electronic and Information Engineering, Soochow University, Suzhou, Jiangsu 215006, China State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions and Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, China;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Intraocular pressure; flexible sensor; droplet-based force sensor; SS-OCT;

    机译:眼压;柔性传感器基于液滴的力传感器;光学OCT;

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