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首页> 外文会议>Optical Interactions with Tissue and Cells XVI; Progress in Biomedical Optics and Imaging; vol.6, no.10 >Synergistic effects of laser and adjuvant therapies for cancer - Progress in the development of novel cancer treatment methods using combinations of photothermal, photochemical, immunotherapy and chemotherapy
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Synergistic effects of laser and adjuvant therapies for cancer - Progress in the development of novel cancer treatment methods using combinations of photothermal, photochemical, immunotherapy and chemotherapy

机译：激光和辅助疗法对癌症的协同效应-结合光热，光化学，免疫疗法和化学疗法开发新型癌症治疗方法的进展

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摘要

Combination therapy has been commonly used in chemotherapy, taking advantage of different effects of different chemotherapeutic agents. The treatment effects are often synergistic. The same approach has been investigated in laser phototherapy. Specifically, different combinations of laser photothermal interaction, laser photochemical interaction, immunotherapy and chemotherapy have been used in the treatment of tumors. These novel approaches showed promise in cancer treatment, particularly against metastatic tumors. The recent development in this area is discussed in this paper. Furthermore, a specific combination of photodynamic therapy (PDT) with a novel immunoadjuvant, glycated chitosan (GC), has shown to be effective in the treatment mammary tumors and lung tumors in mice. In the treatment of EMT6 tumor-bearing mice, the Photofrin-based PDT and GC has significantly increased the survival rates from 37.5% with PDT alone to 62.5% when a 0.1-ml 0.5% GC was peritumoral injected immediately after PDT treatment. The survival rate was further increased to 75.0% when GC of higher concentration was used. In comparison, the individual components of the PDT-GC treatment showed either no effect or very limited effects. In the treatment of a poorly immunogenic tumor model, Line 1 lung tumors in mice, the combination of PDT and GC resulted in a 37.5% survival rate, while no survival mice were observed with PDT alone.
机译：利用不同化学治疗剂的不同作用，联合疗法已普遍用于化学疗法。治疗效果通常是协同的。在激光光疗中已经研究了相同的方法。具体地，已经将激光光热相互作用，激光光化学相互作用，免疫疗法和化学疗法的不同组合用于治疗肿瘤。这些新颖的方法在癌症治疗中显示出了希望，特别是针对转移性肿瘤。本文讨论了该领域的最新发展。此外，已将光动力疗法（PDT）与新型免疫佐剂糖化壳聚糖（GC）的特定组合显示出可有效治疗小鼠的乳腺肿瘤和肺部肿瘤。在EMT6荷瘤小鼠的治疗中，基于光敏蛋白的PDT和GC的生存率从单独使用PDT的37.5％显着提高到在PDT治疗后立即在肿瘤周围注射0.1 ml 0.5％GC的存活率，达到62.5％。当使用更高浓度的GC时，存活率进一步提高到75.0％。相比之下，PDT-GC处理的各个成分均未显示效果或效果非常有限。在对免疫原性差的肿瘤模型（小鼠1型肺肿瘤）的治疗中，PDT和GC的组合可导致37.5％的存活率，而单独使用PDT则没有观察到存活小鼠。

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