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首页> 美国政府科技报告 >Preclinical Evaluation of Fever-Range, Whole Body Hyperthermia as a Adjuvant to Chemotherapy and Cytokine Immunotherapy for the Treatment of Breast Cancer
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Preclinical Evaluation of Fever-Range, Whole Body Hyperthermia as a Adjuvant to Chemotherapy and Cytokine Immunotherapy for the Treatment of Breast Cancer

机译：临床前评估发热范围，全身热疗作为化疗和细胞因子免疫疗法的辅助治疗乳腺癌

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This grant was written to examine the effect of combining fever-range heat treatments (WBH) - with cytokine immunotherapy and chemotherapy in a mouse model of human breast cancer. Progress in year number three of this grant has revealed that the 4Tl mouse model is sensitive to WBH, resulting in a tumor growth delay and illustrative of similar effects of heat in other mouse models in the laboratory of the Pi's mentor. In addition, it has been found that the combination of IL-l2 to whole body heat treatment enhances the anti- tumor effect of WBH alone. Mechanisms behind the observed enhancement in anti-tumor response remain to be clearly identified although work using another mouse model for human colon cancer suggests that the down stream effector molecule, IFN- gamma, may play an important role. Unfortunately, many questions remain to be answered with regards to whether or not the anti-tumor effect of a chemotherapeutic drug, Doxorubicin, in both free and liposome- encapsulated form, can be enhanced using WBH. Finally, an examination of the effect of microsphere encapsulated IL-l2 remains to be completed. However, the training value of this grant has still been exceptional over all three years and is viewed by the PI to have been the greatest opportunity and achievement of her graduate career.

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