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首页> 外文会议>Optical methods in developmental biology ; Bioinspired, biointegrated, bioengineered photonic devices >Silicon nanophotonic ring resonator sensors integrated in reaction tubes
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Silicon nanophotonic ring resonator sensors integrated in reaction tubes

机译：集成在反应管中的硅纳米光子环形谐振器传感器

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摘要

Enzyme-linked immunosorbent assays (ELISA) are the most popular immunoassay techniques performed every day in hospitals and laboratories and they are used as a diagnostic tool in medicine and plant pathology, as well as a quality-control check in various industries. However, complex labeling techniques are required to be able to perform the assay and non-specific binding and endpoint timing are difficult to optimize. These issues could be solved by label-free techniques such as silicon nanophotonic microring resonator sensors, but this platform requires complex microfluidics, which is very much removed from the daily practice in e.g. hospital labs, which still relies to a large degree on platforms like 96-well microtiter plates or reaction tubes. To address these issues, here, we propose the combination of a simple and compatible reaction tube platform with label free silicon-on-insulator (SOI) photonic biosensors, where the flow is through the sensor chip as opposed to over the chip as in more conventional approaches. This device allows real time detection and analysis. Its great flexibility and small footprint make it ideal for an easy handling in any laboratory.
机译：酶联免疫吸附测定（ELISA）是医院和实验室每天最常用的免疫测定技术，它们被用作医学和植物病理学的诊断工具，以及各个行业的质量控制检查。但是，需要复杂的标记技术才能执行测定，并且非特异性结合和终点时间很难优化。这些问题可以通过诸如硅纳米光子微环谐振器传感器之类的无标签技术来解决，但是该平台需要复杂的微流控技术，例如，从日常实践中已将其去除了很多。医院实验室，在很大程度上仍依赖于96孔微量滴定板或反应管等平台。为了解决这些问题，在这里，我们建议将简单且兼容的反应管平台与无标记绝缘体上硅（SOI）光子生物传感器结合使用，其中流是通过传感器芯片而不是通过芯片的。常规方法。该设备允许实时检测和分析。它具有极大的灵活性和占地面积小，非常适合在任何实验室中轻松处理。

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  • 来源
  • 会议地点 San Francisco CA(US)
  • 作者

    C. Lerma Arce; A. Goes; E. Hallynck; P. Dubruel; K. Komorowska; S. Van Put; P.Bienstman;

  • 作者单位

    Photonics Research Group (INTEC) Gent University, Sint-Pietersnieuwstraat 41, 9000 Gent, Belgium,Center for Nano- and Biophotonics, Gent University, 9000 Gent, Belgium;

    Polymer Chemistry and Biomaterials Group, Gent University, Krijgslaan 281 (S4), 9000 Gent, Belgium,Center for Nano- and Biophotonics, Gent University, 9000 Gent, Belgium;

    Photonics Research Group (INTEC) Gent University, Sint-Pietersnieuwstraat 41, 9000 Gent, Belgium,Center for Nano- and Biophotonics, Gent University, 9000 Gent, Belgium;

    Polymer Chemistry and Biomaterials Group, Gent University, Krijgslaan 281 (S4), 9000 Gent, Belgium,Center for Nano- and Biophotonics, Gent University, 9000 Gent, Belgium;

    Photonics Research Group (INTEC) Gent University, Sint-Pietersnieuwstraat 41, 9000 Gent, Belgium,Center for Nano- and Biophotonics, Gent University, 9000 Gent, Belgium;

    Center for MicroSystems Technology, Gent University, Technologiepark 914, 9052 Zwijnaarde (Gent), Belgium;

    Photonics Research Group (INTEC) Gent University, Sint-Pietersnieuwstraat 41, 9000 Gent, Belgium,Center for Nano- and Biophotonics, Gent University, 9000 Gent, Belgium;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Silicon nanophotonic sensors; photonic microring resonators; Silicon-on-Insulator (SOI); reaction tubes; Enzyme-linked immunosorbert assay (ELISA);

    机译：硅纳米光子传感器；光子微环谐振器；绝缘体上硅（SOI）；反应管酶联免疫吸附测定（ELISA）;

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