• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Optical methods for tumor treatment and detection: Mechanisms and techniques in photodynamic therapy XIX >Theranostic Nanocells for Simultaneous Imaging and Photodynamic therapy of Pancreatic Cancer
【24h】

Theranostic Nanocells for Simultaneous Imaging and Photodynamic therapy of Pancreatic Cancer

机译：胰腺癌同时成像和光动力疗法的治疗性纳米细胞

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Nanotechnology has the potential to deliver multiple imaging and therapeutic agents to the "right place at the right time". This could dramatically improve treatment responses in cancer which have been so far, dismal as well as allow us to monitor this response online. Pancreatic cancer (PanCa) has a poor prognosis with a 5-year survival rate of only 5% and there is a desperate need for effective treatments. Photodynamic therapy (PDT) has shown promising results in treating PanCa. Mechanism-based combinations with PDT have enhanced treatment outcome. Agents tested with PDT include Avastin, an antibody against vascular endothelial growth factor (VEGF) which is approved for treating various cancers. Here, we investigate the effect of neutralizing intracellular VEGF using nanotechnology for the delivery of Avastin in combination with PDT. For this we used a construct called "nanocells" in which the photosensitizer was trapped inside polymer nanoparticles and these, with Avastin, were then encapsulated inside liposomes. Simultaneous delivery of drugs in nano-constructs could improve the treatment response of mechanism based combination therapies against cancer. Our studies demonstrate significant enhancement in treatment outcomes when nanocell-based PDT is combined with Avastin in orthotopic PanCa mouse models. We propose a new paradigm for Avastin-based therapy by combining intracellular delivery of the antibody and PDT using nanotechnology for treating PanCa.
机译：纳米技术具有将多种成像和治疗剂输送到“在正确的时间正确的位置”的潜力。到目前为止，这可以极大地改善癌症的治疗反应，令人沮丧，并使我们能够在线监测此反应。胰腺癌（PanCa）的预后较差，其5年生存率仅为5％，因此迫切需要有效的治疗方法。光动力疗法（PDT）在治疗PanCa中显示出可喜的结果。基于机制的PDT组合可增强治疗效果。用PDT测试的药物包括Avastin，一种抗血管内皮生长因子（VEGF）的抗体，已被批准用于治疗各种癌症。在这里，我们研究了使用纳米技术中和PDT与Avastin传递中和细胞内VEGF的作用。为此，我们使用了一种称为“纳米细胞”的构建体，其中光敏剂被捕获在聚合物纳米颗粒内部，然后将它们与Avastin一起封装在脂质体内。在纳米结构中同时递送药物可以改善基于机制的联合疗法对癌症的治疗反应。我们的研究表明，在原位PanCa小鼠模型中，将基于纳米细胞的PDT与Avastin结合后，治疗效果显着提高。我们通过使用纳米技术治疗PanCa结合抗体和PDT的细胞内递送，为基于Avastin的治疗提出了新的范例。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号