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A study of light fluence rate distribution for PDT using MC simulation

机译：用MC模拟研究PDT的光通量率分布。

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In photodynamic therapy (PDT), it is essential to accurately determine the light fluence rate distribution from the known treatment geometry and optical properties. The light distribution calculation for intracavitory PDT is a complex problem because the light near the tissue surface inside the cavity is influenced by the geometry of the surrounding tissue, by multiply scattered light inside the cavity, and by possible attenuation of the fluid contained within the cavity. To address this problem we use Monte Carlo simulations as a gold standard to calculate the light fluence in a spherical cavity, both with homogenous and inhomogeneous optical property distributions. The MC code is developed in the Matlab platform with the Fresnel reflection well defined at the tissue-medium boundary, allowing the number of times a photon can be scattered within the cavity to be user specified. We find that increasing the attenuation, causes a decrease the light fluence rate for the same total light power from a point source. The resulting fluence rate is then compared with our empirical model based on diffusion. Preliminary results of comparisons of the MC simulation and the empirical model will be presented. We conclude that the empirical model is adequate for modeling light fluence within the cavity.
机译：在光动力疗法（PDT）中，必须根据已知的治疗几何形状和光学特性准确确定光通量率分布。腔内PDT的光分布计算是一个复杂的问题，因为腔内组织表面附近的光受周围组织的几何形状，腔内散射光的倍增以及腔内所含流体的可能衰减的影响。为了解决这个问题，我们使用蒙特卡罗模拟作为黄金标准来计算球面腔中的光通量，该光通量具有均一和不均一的光学特性分布。 MC代码是在Matlab平台上开发的，菲涅耳反射在组织-介质边界处定义得很好，从而允许光子在腔内被散射的次数由用户指定。我们发现，对于来自点光源的相同总光功率，增加衰减会导致光通量率降低。然后将产生的通量率与基于扩散的经验模型进行比较。将给出MC模拟和经验模型比较的初步结果。我们得出的结论是，经验模型足以用于模拟腔内的光通量。

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