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Determining how uncertainties in optical properties affect light dose calculations for PDT

机译:确定光学特性的不确定性如何影响PDT的光剂量计算

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The effectiveness of photodynamic treatment depends on several factors including an accurate knowledge of optical properties of the tissue to be treated. In order to correctly determine the needed light dose, the values of tissue optical properties must be well known. In this study we consider how the uncertainties in the measured values of optical properties affect the uncertainty in light dosimetry. By using phantoms with known optical properties we determine the uncertainties for several algorithms currently in the literature. We calculate the light fluence uncertainties using a finite element model solution to the diffusion equation in a cavity geometry. Using these uncertainties we conduct a statistical analysis, building a three dimensional space of uncertainties in μ_a, μ_s, and light dose. By characterizing this space we gain an understanding of the trend in uncertainties and determine which algorithms provide the most accurate light dose.
机译:光动力治疗的有效性取决于几个因素,包括对要治疗的组织的光学特性的准确了解。为了正确地确定所需的光剂量,组织光学特性的值必须是众所周知的。在这项研究中,我们考虑了光学性能测量值的不确定性如何影响光剂量学的不确定性。通过使用具有已知光学特性的体模,我们可以确定目前文献中几种算法的不确定性。我们使用有限元模型求解腔几何形状中的扩散方程来计算光通量不确定性。使用这些不确定性,我们进行了统计分析,建立了μ_a,μ_s和光剂量的不确定性的三维空间。通过表征该空间,我们可以了解不确定性的趋势,并确定哪种算法可以提供最准确的光剂量。

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