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首页> 外文会议>Optical methods for tumor treatment and detection: mechanisms and techniques in photodynamic therapy XXI >Optimization of parameters in photodynamic therapy to kill p. aeruginosa with 809-nm diode laser and indocyanine green
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Optimization of parameters in photodynamic therapy to kill p. aeruginosa with 809-nm diode laser and indocyanine green

机译：优化光动力疗法杀死p的参数。带有809 nm二极管激光器和吲哚菁绿的铜绿

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The emergence of antibiotic resistant bacteria causes significant increase in deaths due to infections around the world. Nowadays, it could be impossible to fmd appropriate antibiotics to treat some bacterial strains, especially multidrug resistant types. Therefore, there is an urgent need to develop new and safe treatment techniques for multidrug resistant bacteria associated morbidity and mortality. In this study, Photodynamic Therapy was used to destroy these kinds of bacteria with near infrared light and Indocyanine Green. Different wavelengths of lasers mostly in the visible spectrum have been investigated for Photodynamic Therapy; however near infrared lasers have been used in very few studies. The main motivation to test photodynamic therapy with near infrared light and indocyanine green is that the near infrared laser (around 800-nm) has more penetration depth in the biological tissue than the other lasers have. Therefore it is supposed that it will show more antibacterial effect. And also indocyanine green has a very low toxicity and an FDA-approved drug. This study investigated optimum parameters for PDT with 809-nm laser and Indocyanine green (ICG) to kill P. aeruginosa in vitro. We were able to optimize the laser power and ICG concentration to non-toxic levels and achieved 99% decrease in bacterial load with 252 J/cm2 laser light and 125 μg/ml ICG concentration. This study demonstrates that PDT with near-infrared light and ICG can be powerful and non-hazardous treatment strategy for unbeatable pathogens.
机译：抗生素抗性细菌的出现导致世界范围内由于感染引起的死亡人数大幅增加。如今，不可能找到合适的抗生素来治疗某些细菌菌株，尤其是对多药耐药的菌株。因此，迫切需要开发新的和安全的治疗技术，用于与疾病和死亡率相关的多药耐药细菌。在这项研究中，光动力疗法被用于通过近红外光和吲哚菁绿破坏这些细菌。已经研究了主要在可见光谱中的不同波长的激光用于光动力疗法。然而，很少有研究使用近红外激光。测试用近红外光和吲哚菁绿进行光动力疗法的主要动机是，近红外激光（约800 nm）在生物组织中的穿透深度比其他激光器要大。因此推测它会显示更多的抗菌作用。吲哚菁绿还具有极低的毒性和FDA批准的药物。这项研究调查了使用809 nm激光和吲哚菁绿（ICG）杀灭铜绿假单胞菌的PDT的最佳参数。我们能够将激光功率和ICG浓度优化到无毒水平，并通过252 J / cm2激光和125μg/ ml ICG浓度实现了99％的细菌减少。这项研究表明，带有近红外光的PDT和ICG可以成为无与伦比的病原体的有力且无害的治疗策略。

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