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首页> 外文会议>Optical methods for tumor treatment and detection: mechanisms and techniques in photodynamic therapy XXII >Noninvasive imaging of absolute PpⅨ concentration distribution in nonmelanoma skin tumors at pre-PDT
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Noninvasive imaging of absolute PpⅨ concentration distribution in nonmelanoma skin tumors at pre-PDT

机译：PDT前非黑素瘤皮肤肿瘤中PpⅨ绝对浓度分布的无创成像

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Photodynamic Therapy (PDT) has proven to be an effective treatment option for nonmelanoma skin cancers. The ability to quantify the concentration of drug in the treated area is crucial for effective treatment planning as well as predicting outcomes. We utilized spatial frequency domain imaging for quantifying the accurate concentration of protoporphyrin Ⅸ (PpⅨ) in phantoms and in vivo. We correct fluorescence against the effects of native tissue absorption and scattering parameters. First we quantified the absorption and scattering of the tissue non-invasively. Then, we corrected raw fluorescence signal by compensating for optical properties to get the absolute drug concentration. After phantom experiments, we used basal cell carcinoma (BCC) model in Gli mice to determine optical properties and drug concentration in vivo at pre-PDT.
机译：光动力疗法（PDT）已被证明是非黑色素瘤皮肤癌的有效治疗选择。量化治疗区域中药物浓度的能力对于有效的治疗计划以及预测结果至关重要。我们利用空间频域成像技术来量化幻影和体内原卟啉Ⅸ（PpⅨ）的准确浓度。我们针对天然组织吸收和散射参数的影响校正荧光。首先，我们无创地定量了组织的吸收和散射。然后，我们通过补偿光学性能来校正原始荧光信号，以获得绝对药物浓度。经过幻像实验，我们在Gli小鼠中使用了基底细胞癌（BCC）模型来确定PDT前体内的光学性质和体内药物浓度。

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