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An ultrasound-guided fluorescence tomography system: design and specification

机译:超声引导荧光层析成像系统:设计和规格

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An ultrasound-guided fluorescence molecular tomography system is under development for in vivo quantification of Protoporphyrin Ⅸ (PpⅨ) during Aminolevulinic Acid - Photodynamic Therapy (ALA-PDT) of Basal Cell Carcinoma. The system is designed to combine fiber-based spectral sampling of PPⅨ fluorescence emission with co-registered ultrasound images to quantify local fluorophore concentration. A single white light source is used to provide an estimate of the bulk optical properties of tissue. Optical data is obtained by sequential illumination of a 633nm laser source at 4 linear locations with parallel detection at 5 locations interspersed between the sources. Tissue regions from segmented ultrasound images, optical boundary data, white light-informed optical properties and diffusion theory are used to estimate the fluorophore concentration in these regions. Our system and methods allow interrogation of both superficial and deep tissue locations up to PpⅨ concentrations of 0.025ug/ml.
机译:超声引导的荧光分子断层成像系统正在开发中,用于在基础细胞癌的氨基乙酰丙酸-光动力疗法(ALA-PDT)期间对原卟啉Ⅸ(PpⅨ)进行体内定量。该系统旨在将基于纤维的PPⅨ荧光发射光谱采样与共同注册的超声图像结合起来,以量化局部荧光团浓度。单个白光源用于提供组织的整体光学特性的估计。通过在4个线性位置上连续照射633nm激光源并在散布在光源之间的5个位置处进行平行检测,可以获得光学数据。来自分段超声图像的组织区域,光学边界数据,白光通知的光学特性和扩散理论被用于估计这些区域中的荧光团浓度。我们的系统和方法允许对浅表组织和深部组织位置进行询问,直到PpⅨ浓度为0.025ug / ml。

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