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Effectiveness of porphyrin-like compounds in photodynamic damage of atherosclerotic plaque

机译：卟啉样化合物在动脉粥样硬化斑块光动力损伤中的作用

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Abstract: Porphyrin-like compounds such as tetra-(4 sulfonatophenyl) porphine (TSPP), chlorin-e$-6$/ derivative (CED) and tetrasulfophthalocyanin (TSPC) are photosensitizing agents that absorbed light at 630 nm, 657 nm and 625 nm, respectively, and bind preferentially to atherosclerotic plaque. Porphyrin-treated human cadaveric aorta was compared with untreated aorta using several techniques: the absorptive spectrophotometry which has demonstrated the distinct absorptive peaks at 630 nm, 657 nm, 625 nm in porphyrin-treated plaque which were absent in untreated normal aorta; the fluorescence microscopy, which has shown that the treated atheroma acquired the characteristic fluorescence of porphyrin under ultraviolet light. Because of the porphyrin's unique property, porphyrin-treated and untreated aorta was exposed to red laser radiation at a wavelength of 632.8 nm. It was found that enhanced photoalteration of porphyrin-treated compared with untreated atheroma. Histologic analysis of the depth of tissue penetration of equal amounts of laser radiation has demonstrated more pronounced photosensitizing effect in TSPC-treated plaque compared with CED-, TSPP-, and untreated plaques. This study demonstrates a potential of tetrasulfophthalocyanin for selective alteration of atheroma by He-Ne laser radiation.!
机译：摘要：卟啉样化合物如四-（4-磺酰基苯基）卟啉（TSPP），二氢卟酚-e $ -6 $ /衍生物（CED）和四磺酞菁（TSPC）是在630 nm，657 nm和625处吸收光的光敏剂。分别与nm和优先结合到动脉粥样硬化斑块。用几种技术比较了用卟啉处理的人尸体主动脉和未处理的主动脉：吸收分光光度法已证明在用卟啉处理的斑块中在630 nm，657 nm，625 nm处有明显的吸收峰，而在未经处理的正常主动脉中则没有。荧光显微镜显示，治疗后的动脉粥样硬化在紫外光下获得了卟啉的特征荧光。由于卟啉的独特性质，经卟啉处理的主动脉和未经处理的主动脉都暴露于波长为632.8 nm的红色激光辐射中。发现与未经处理的动脉粥样硬化相比，经卟啉处理的光增高作用增强。对等量激光辐射的组织穿透深度的组织学分析表明，与CED，TSPP和未处理的斑块相比，TSPC处理的斑块具有更明显的光敏作用。这项研究证明了四磺酞菁具有通过He-Ne激光辐射选择性改变动脉粥样硬化的潜力。

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