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首页> 外文会议>Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques >Photosensitization is required for antiretroviral activity of hypericin
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Photosensitization is required for antiretroviral activity of hypericin

机译：光敏剂是金丝桃素的抗逆转录病毒活性所必需的

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Abstract: In a seminal series of papers, Meruelo and co-workers have described the potent antiretroviral effect of hypericin. Interestingly, hypericin was found to inhibit not only the production of infectious virus from chronically infected cells, but was also shown to directly inhibit reverse transcriptase activity of mature virions. The effect of hypericin on cells chronically infected with equine infectious anemia virus (EIAV), a retrovirus genetically related to HIV, is demonstrated. At concentrations of 10 $mu@g/ml, hypericin reduced production of infectious EIAV by 99.99% without causing obvious cytopathic effects. Interestingly, the results indicated that the antiretroviral activity of hypericin was wholly dependent on the presence of light. No decrease in viral infectivity was observed when hypericin and virus were incubated in the dark. Moreover, it appeared that light was an absolute requirement for the antiviral activity, as even high concentrations of hypericin (10 $mu@g/ml) were unable to reduce infectivity of as few as 100 infectious virions.!
机译：摘要：Meruelo及其同事在一系列开创性的论文中描述了金丝桃素的有效抗逆转录病毒作用。有趣的是，发现金丝桃素不仅抑制慢性感染细胞产生传染性病毒，而且还显示出它直接抑制成熟病毒体的逆转录酶活性。证明了金丝桃素对马感染性贫血病毒（EIAV）（一种与HIV遗传相关的逆转录病毒）慢性感染的细胞的作用。在浓度为10μμg/ ml的情况下，金丝桃素可将感染性EIAV的产生降低99.99％，而不会引起明显的细胞病变作用。有趣的是，结果表明金丝桃素的抗逆转录病毒活性完全取决于光的存在。金丝桃素和病毒在黑暗中孵育时，未观察到病毒感染性降低。而且，似乎光是抗病毒活性的绝对要求，因为即使高浓度的金丝桃素（10μg/ ml）也无法减少多达100个感染性病毒体的感染力。

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