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Photosensitization is required for antiretroviral activity of hypericin

机译：高蛋白抗逆转录病毒活性需要光敏化

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In a seminal series of papers, Meruelo and co-workers have described the potent antiretroviral effect of hypericin. Interestingly, hypericin was found to inhibit not only the production of infectious virus from chronically infected cells, but was also shown to directly inhibit reverse transcriptase activity of mature virions. The effect of hypericin on cells chronically infected with equine infectious anemia virus (EIAV), a retrovirus genetically related to HIV, is demonstrated. At concentrations of 10 $mu@g/ml, hypericin reduced production of infectious EIAV by 99.99% without causing obvious cytopathic effects. Interestingly, the results indicated that the antiretroviral activity of hypericin was wholly dependent on the presence of light. No decrease in viral infectivity was observed when hypericin and virus were incubated in the dark. Moreover, it appeared that light was an absolute requirement for the antiviral activity, as even high concentrations of hypericin (10 $mu@g/ml) were unable to reduce infectivity of as few as 100 infectious virions.
机译：在一篇各点的论文中，Meruelo和同事已经描述了高霉素的有效的抗逆转录病毒效应。有趣的是，丙晶菌素不仅抑制了来自慢性感染的细胞的传染性病毒的产生，而且还显示出直接抑制成熟病毒藻的逆转录酶活性。鉴于血清感染性贫血病毒（EIAV）慢性感染血清血清血管病毒的血清血清血清血清血清效果，归因于与艾滋病毒遗传相关。在10 $ MU @ g / ml的浓度下，高蛋白减少了99.99％的传染性EIAV的产量，不会导致明显的细胞病变作用。有趣的是，结果表明，高蛋白的抗逆转录病毒活性完全依赖于光的存在。当在黑暗中孵育高蛋白和病毒时，观察到病毒感染性的降低。此外，似乎光是对抗病毒活性的绝对要求，因为甚至高浓度的高霉素（10 $ MU @ G / ml）无法降低少数传染病病毒的感染性。

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