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首页> 外文会议>Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques >Photodynamic therapy of malignant brain tumors: supplementary postoperative light delivery by implanted optical fibers: field fractionation
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Photodynamic therapy of malignant brain tumors: supplementary postoperative light delivery by implanted optical fibers: field fractionation

机译：恶性脑肿瘤的光动力疗法：植入式光纤补充术后光传递：视野分割

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Abstract: Sixty-three patients with malignant brain tumors weretreated with intraoperative photodynamic therapy (PDT)using an argon dye pump laser and preoperativelyadministered hematoporphyrin derivative ordihematoporphyrin ether. In 13 cases, in addition tocavitary photo-illumination, cylindrical diffusionfibers were used to increase the amount of light energyadministered to the tumor tissue intraoperatively. Thisinterstitial photo-illumination was tolerated at lightenergy densities of less than 450 J/cm. In six recentcases, all of whom had large malignant gliomas andcould not be illuminated adequately at a singlesession, cylindrical diffusion fibers were left in situafter intraoperative cavitary photo-illumination of thetumor residuum. The fibers were protected fromfracturing by placing all but the exposed diffusing endin a red rubber catheter of the appropriate diameter.The fibers were externalized through a separate stabwound as would be the case for a ventricular drain.Photo-illumination was continued one or two dayspost-operatively. The optimal fiber couple to the argondye pump laser was achieved by assessing the fiber sidescatter with a photometer. These six patients received585-2730 Joules during the post-operativephoto-illumination. The patients tolerated thefractionated photo-illumination well. A transient scalpinflammation occurred as the consequence lighttransmission to skin from the implanted fibers in onecase. The median survival for the whole series was 8.5months (40 weeks) with a 1- and 2-year actuarialsurvival rate of 33% and 14%, respectively.!
机译：摘要：对63例恶性脑肿瘤患者进行术中光动力疗法（PDT），使用氩染料泵浦激光并术前给予血卟啉衍生物或邻二血卟啉醚。在13例病例中，除了腔内光照射外，还使用了圆柱状扩散纤维来增加术中向肿瘤组织施加的光能。间隙光照明在光能密度小于450 J / cm时是可以容忍的。在最近的六例病例中，所有病例均患有大的恶性神经胶质瘤，无法在一次治疗中得到充分的照明，在术中对残留的残留物进行腔内光照明后，原位留有圆柱状扩散纤维。通过将裸露的裸露末端全部裸露在适当直径的红色橡胶导管中，保护纤维免于破裂。通过心室引流的情况，通过单独的刺伤将纤维外部化。在光照后一到两天继续进行光照明。操作上。通过用光度计评估光纤的侧向散射，可以实现与氩泵浦激光器的最佳光纤耦合。这六名患者在术后光照射期间接受了585-2730焦耳的能量。患者对普通的光照射耐受良好。在一种情况下，由于植入的纤维向皮肤的光透射而发生了短暂的头皮发炎。整个系列的中位生存期为8.5个月（40周），1年和2年精算生存率分别为33％和14％。

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