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首页> 外文会议>Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques >Photodynamic therapy of malignant brain tumors: supplementarypostoperative light delivery by implanted optical fibers: field fractionation,
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Photodynamic therapy of malignant brain tumors: supplementarypostoperative light delivery by implanted optical fibers: field fractionation,

机译：恶性脑肿瘤的光动力疗法：通过植入的光纤补充术后光：场分割，

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Abstract: Sixty-three patients with malignant brain tumors were treated with intraoperative photodynamic therapy (PDT) using an argon dye pump laser and preoperatively administered hematoporphyrin derivative or dihematoporphyrin ether. In 13 cases, in addition to cavitary photo-illumination, cylindrical diffusion fibers were used to increase the amount of light energy administered to the tumor tissue intraoperatively. This interstitial photo-illumination was tolerated at light energy densities of less than 450 J/cm. In six recent cases, all of whom had large malignant gliomas and could not be illuminated adequately at a single session, cylindrical diffusion fibers were left in situ after intraoperative cavitary photo-illumination of the tumor residuum. The fibers were protected from fracturing by placing all but the exposed diffusing end in a red rubber catheter of the appropriate diameter. The fibers were externalized through a separate stab wound as would be the case for a ventricular drain. Photo-illumination was continued one or two days post-operatively. The optimal fiber couple to the argon dye pump laser was achieved by assessing the fiber side scatter with a photometer. These six patients received 585-2730 Joules during the post-operative photo-illumination. The patients tolerated the fractionated photo-illumination well. A transient scalp inflammation occurred as the consequence light transmission to skin from the implanted fibers in one case. The median survival for the whole series was 8.5 months (40 weeks) with a 1- and 2-year actuarial survival rate of 33% and 14%, respectively.!
机译：摘要：对63例恶性脑肿瘤患者进行术中光动力疗法（PDT），使用氩染料泵浦激光治疗，术前给予血卟啉衍生物或二血卟啉醚。在13例病例中，除了腔内光照射外，还使用了圆柱状扩散纤维来增加术中给予肿瘤组织的光能。间隙光照明在小于450 J / cm的光能密度下是可以容忍的。在最近的6例病例中，所有人均患有大的恶性神经胶质瘤，一次不能被充分照明，在术中对肿瘤残留进行腔内光照明后，圆柱状扩散纤维留在原位。通过将裸露的扩散端以外的所有端头放到适当直径的红色橡胶导管中，防止纤维破裂。纤维通过单独的刺伤伤口被外部化，就像心室引流一样。术后一两天继续进行光照明。通过用光度计评估光纤的侧向散射，可以实现与氩染料泵浦激光器的最佳光纤耦合。这六名患者在术后光照射期间接受了585-2730焦耳的能量。患者很好地耐受了分光照射。在一种情况下，由于从植入的纤维向皮肤的光传输而发生了短暂的头皮发炎。整个系列的中位生存期为8.5个月（40周），一年和两年精算生存率分别为33％和14％。

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