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The reversibility of morphological changes in the mesenteric lymph nodes after peroral administration of gold nanoparticles

机译:口服金纳米颗粒后肠系膜淋巴结形态变化的可逆性

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The oral administration of gold nanoparticles at dose 190 mg /kg animal body weight during 8 days leads to changes in the cellular composition of the mesenteric lymph nodes, the severity and reversibility of the reaction was determined by the size of gold nanoparticles. The cellular composition of the lymph nodes after the introduction of gold nanoparticle size of 1-3 nm for 8 days corresponded the control values, indicating the absence of immunotoxicity. Duration of recovery of cellular composition of the lymph nodes after administration of gold nanoparticles with size 15 nm and 50 nm does not exceed 21 days. It can be concluded that 15 nm and 50 nm nanoparticles have no immunotoxic action at oral administration.
机译:在8天内以190 mg / kg动物体重的剂量口服金纳米颗粒会导致肠系膜淋巴结细胞组成的变化,反应的严重程度和可逆性由金纳米颗粒的大小决定。引入1-3 nm的金纳米颗粒8天后,淋巴结的细胞组成与对照值相对应,表明没有免疫毒性。施用大小为15 nm和50 nm的金纳米颗粒后,淋巴结细胞成分恢复的持续时间不超过21天。可以得出结论,口服15 nm和50 nm纳米颗粒没有免疫毒性作用。

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