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PDT-treated apoptotic cells induce macrophage synthesis NO

机译：PDT处理的凋亡细胞诱导巨噬细胞合成NO

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摘要

Nitric oxide (NO) is a biologically active molecule which has multi-functional in different species. As a second messenger and neurotransmitter, NO is not only an important regulatory factor between cells' information transmission, but also an important messenger in cell-mediated immunity and cytotoxicity. On the other side, NO is involving in some diseases' pathological process. In pathological conditions, the macrophages are activated to produce a large quantity of nitric oxide synthase (iNOS), which can use L-arginine to produce an excessive amount of NO, thereby killing bacteria, viruses, parasites, fungi, tumor cells, as well as in other series of the immune process. In this paper, photofrin-based photodynamic therapy (PDT) was used to treat EMT6 mammary tumors in vitro to induce apoptotic cells, and then co-incubation both apoptotic cells and macrophages, which could activate macrophage to induce a series of cytotoxic factors, especially NO. This, in turn, utilizes macrophages to activate a cytotoxic response towards neighboring tumor cells. These results provided a new idea for us to further study the immunological mechanism involved in damaging effects of PDT, also revealed the important function of the immune effect of apoptotic cells in PDT.
机译：一氧化氮（NO）是在不同物种中具有多功能的生物活性分子。作为第二种信使和神经递质，NO不仅是细胞信息传递之间的重要调控因子，而且还是细胞介导的免疫和细胞毒性的重要信使。另一方面，NO参与某些疾病的病理过程。在病理情况下，巨噬细胞被激活以产生大量的一氧化氮合酶（iNOS），后者可以使用L-精氨酸产生过量的NO，从而杀死细菌，病毒，寄生虫，真菌，肿瘤细胞就像其他系列的免疫过程一样。本文采用基于光敏蛋白的光动力疗法（PDT）在体外治疗EMT6乳腺肿瘤以诱导凋亡细胞，然后共同孵育凋亡细胞和巨噬细胞，从而激活巨噬细胞以诱导一系列细胞毒性因子，特别是没有。反过来，这利用巨噬细胞激活对邻近肿瘤细胞的细胞毒性反应。这些结果为我们进一步研究PDT损伤作用的免疫机制提供了新思路，也揭示了PDT中凋亡细胞免疫作用的重要作用。

著录项

  • 来源
    《Optical trapping and microscopic imaging》|2009年|P.75070F.1-75070F.10|共10页
  • 会议地点 Shanghai(CN);Shanghai(CN)
  • 作者

    S. Song; D. Xing; F.F. Zhou; W.R. Chen;

  • 作者单位

    MOE Key Laboratory of Laser Life Science Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China;

    MOE Key Laboratory of Laser Life Science Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China;

    MOE Key Laboratory of Laser Life Science Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China;

    MOE Key Laboratory of Laser Life Science Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China Biomedical Engineering Program, Department of Engineering and Physics, College of Mathematics and Science, University of Central Oklahoma, Edmond, Oklahoma 73034, USA;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 光学仪器;信息处理（信息加工）;
  • 关键词

    apoptotic cell; nitric oxide; photodynamic therapy; macrophage; tumor cells;

    机译：凋亡细胞一氧化氮;光动力疗法；巨噬细胞肿瘤细胞;

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