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首页> 外文会议>Optics in health care and biomedical optics IV >A novel nasopharyngeal cancer detection based on plasma SERS combined with PCA-LDA statistical analysis
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A novel nasopharyngeal cancer detection based on plasma SERS combined with PCA-LDA statistical analysis

机译：基于血浆SERS结合PCA-LDA统计分析的新型鼻咽癌检测

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摘要

In order to develop a novel and simple blood test for non-invasive nasopharyngeal cancer detection, a surface-enhanced Raman spectroscopy (SERS) method was presented for blood plasma biochemical analysis. High quality SERS spectrum from human plasma-Ag NP mixture can be obtained using a confocal Raman system. SERS measurements were performed on normal and cancer groups of plasma samples. The measured SERS spectra revealed some specific biomolecular differences in nasopharyngeal cancer plasma. Principal component analysis of the measured SERS spectra separated the spectral features of the two groups into two distinct clusters with little overlaps. Linear discriminate analysis based on the PCA generated features differentiated the nasopharyngeal cancer SERS spectra from normal SERS spectra with high sensitivity (97.7%) and specificity (100%). The results from this exploratory study illustrated great promising for developing SERS human plasma analysis into a clinical tool for non-invasive detection of nasopharyngeal cancers.
机译：为了开发一种新颖，简单的血液检测用于非侵入性鼻咽癌检测，提出了一种用于血浆生化分析的表面增强拉曼光谱（SERS）方法。使用共聚焦拉曼系统可以从人血浆-Ag NP混合物中获得高质量的SERS光谱。对血浆样品的正常和癌症组进行了SERS测量。测得的SERS光谱揭示了鼻咽癌血浆中某些特定的生物分子差异。对测得的SERS光谱进行主成分分析，将两组的光谱特征分成两个几乎没有重叠的不同簇。基于PCA生成特征的线性判别分析以高灵敏度（97.7％）和特异性（100％）将鼻咽癌SERS光谱与正常SERS光谱区分开来。这项探索性研究的结果表明，将SERS人体血浆分析发展为用于非侵入性检测鼻咽癌的临床工具的巨大前景。

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  • 来源
    《Optics in health care and biomedical optics IV》|2010年|p.78452C.1-78452C.6|共6页
  • 会议地点 Beijing(CN)
  • 作者

    Shangyuan Feng; Juqiang Lin; Jianji Pan; Jiesi Chen; Yongzeng Li; Yanan Wu; Haishan Zeng; Rong Chen;

  • 作者单位

    Key Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou 350007, China;

    rnKey Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou 350007, China;

    rnFujian Provincial Tumor Hospital, Fuzhou 350001, China;

    rnKey Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou 350007, China;

    rnKey Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou 350007, China;

    rnFujian Provincial Hospital, Fuzhou, 350001, Fujian, China;

    rnCancer Imaging Department, British Columbia Cancer Research Centre, Vancouver, B.C., Canada;

    rnKey Laboratory of OptoElectronic Science and Technology for Medicine, Ministry of Education, Fujian Normal University, Fuzhou 350007, China;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 光、激光生物医学;
  • 关键词

    SERS; Human plasma; Nasopharyngeal cancer; Cancer detection.;

    机译：SERS;人体血浆鼻咽癌；癌症检测。;
  • 入库时间 2022-08-26 13:44:48

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