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Photoacoustic signal simulation and detection optimization based on laser-scanning optical-resolution photoacoustic microscopy

机译:基于激光扫描光学分辨率光声显微镜的光声信号仿真与检测优化

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摘要

Laser-scanning optical-resolution photoacoustic microscopy (LSOR-PAM) has a high application potential in ophthalmology and other clinical fields because of its high resolution and imaging speed. The stationary unfocused ultrasonic transducer of this system decides the efficiency and field of view (FOV) of photoacoustic signal detection, but the refraction and attenuation of laser generated photoacoustic signal in different tissue mediums will cause signal strength and direction distribution uneven. In this study, we simulated the photoacoustic signal propagation and detection in compound medium models with different tissue parameters using k-space method based on LSOR-PAM imaging principle. The results show a distance related signal strength attenuation and FOV changes related to transducer angle. Our study provides a method for photoacoustic signal detection optimization for different complex tissue structure with LSOR-PAM.
机译:激光扫描光学分辨率光声显微镜(LSOR-PAM)由于其高分辨率和成像速度而在眼科和其他临床领域具有很高的应用潜力。该系统的固定式非聚焦超声换能器决定了光声信号检测的效率和视场(FOV),但是激光在不同组织介质中产生的光声信号的折射和衰减将导致信号强度和方向分布不均。在这项研究中,我们基于LSOR-PAM成像原理,使用k空间方法模拟了具有不同组织参数的复合介质模型中的光声信号传播和检测。结果表明,距离相关的信号强度衰减和FOV变化与换能器角度有关。我们的研究提供了一种使用LSOR-PAM对不同复杂组织结构进行光声信号检测优化的方法。

著录项

  • 来源
    《Optics in health care and biomedical optics VI》|2014年|92682R.1-92682R.7|共7页
  • 会议地点 Beijing(CN)
  • 作者单位

    School of Biomedical Engineering, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai 200240, China;

    School of Biomedical Engineering, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai 200240, China;

    School of Biomedical Engineering, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai 200240, China;

    School of Biomedical Engineering, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai 200240, China;

    School of Biomedical Engineering, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai 200240, China;

    School of Biomedical Engineering, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai 200240, China;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Photoacoustic microscopy; signal simulation; compound medium model;

    机译:光声显微镜;信号模拟复合介质模型;

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