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首页> 外文会议>Oral-Based Diagnostics; Annals of the New York Academy of Sciences; vol.1098 >Genomic Targets in Saliva
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Genomic Targets in Saliva

机译：唾液中的基因组靶标

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摘要

Saliva, the most accessible and noninvasive biofluid of our body, harbors a wide spectrum of biological analytes informative for clinical diagnostic applications. While proteomic constituents are a logical first choice as salivary diagnostic analytes, genomic targets have emerged as highly informative and discriminatory. This awareness, coupled with the ability to harness genomic information by high-throughput technology platforms such as genome-wide microarrays, ideally positions salivary genomic targets for exploring the value of saliva for detection of specific disease states and augmenting the diagnostic and discriminatory value of the saliva proteome for clinical applications. Buccal cells and saliva have been used as sources of genomic DNA for a variety of clinical and forensic applications. For discovery of disease targets in saliva, the recent realization that there is a transcriptome in saliva presented an additional target for oral diagnostics. All healthy subjects evaluated have approximately 3,000 different Mrna molecules in their saliva. Almost 200 of these salivary mRNAs are present in all subjects. Exploration of the clinical utility of the salivary transcriptome in oral cancer subjects shows that four salivary mRNAs (OAZ, SAT, IL8, and Illb) collectively have a discriminatory power of 91% sensitivity and specificity for oral cancer detection. Data are also now in place to validate the presence of unique diagnostic panels of salivary mRNAs in subjects with Sjogren's disease.
机译：唾液是人体中最易接近且无创的生物流体，具有多种生物分析物，可用于临床诊断。虽然蛋白质组学成分作为唾液诊断分析物是合乎逻辑的首选，但基因组靶点已成为具有高度参考价值和歧视性的对象。这种认识以及通过高通量技术平台（例如全基因组微阵列）利用基因组信息的能力，理想地定位了唾液基因组靶标，以探索唾液的价值以检测特定疾病状态并增强该基因的诊断和鉴别价值。用于临床的唾液蛋白质组。颊细胞和唾液已被用作各种临床和法医应用的基因组DNA来源。为了发现唾液中的疾病靶标，最近意识到唾液中有转录组为口腔诊断提供了另一个靶标。评估的所有健康受试者的唾液中大约有3,000种不同的Mrna分子。这些唾液mRNA中几乎有200种存在于所有受试者中。唾液转录组在口腔癌受试者中的临床实用性的探索表明，四个唾液mRNA（OAZ，SAT，IL8和Illb）共同具有91％的敏感性和91％的鉴别力，可用于口腔癌检测。现在也有数据来验证干燥综合征患者唾液mRNA的独特诊断方法的存在。

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