BUILDING MOUSE PHENOTYPE ONTOLOGIES

机译：建立小鼠表型本体

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The structured description of mutant phenotypes presents a major conceptual and practical problem. A general model for generating mouse phenotype ontologies that involves combing a variety of different ontologies to better link and describe phenotypes is presented. This model is based on the Phenotype and Trait Ontology schema proposal and incorporates practical limitations and designing solutions in an attempt to model a testbed for the first phenotype ontology constructed in this manner, namely the mouse behavior phenotype ontology. We propose the application of such a model could provide curators with a powerful mechanism of annotation, mining and knowledge representation as well as achieving some level of free text disassociation.

机译：突变体表型的结构化描述提出了一个主要的概念和实践问题。提出了一种生成小鼠表型本体的通用模型，该模型涉及组合各种不同的本体以更好地链接和描述表型。该模型基于表型和特质本体方案建议，并结合了实际局限性和设计解决方案，以尝试以此方式构建的第一个表型本体（即鼠标行为表型本体）的测试平台建模。我们建议，这种模型的应用可以为策展人提供强大的注释，挖掘和知识表示机制，并实现一定程度的自由文本解除关联。

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《Pacific Symposium on Biocomputing 2004; Jan 6-10, 2004; Hawaii, USA》|2004年|p.178-189|共12页
会议地点 Honolulu HI(US);Honolulu HI(US)
作者
G. V. GKOUTOS; E. C. J. GREEN; A.M. MALLON; J.M. HANCOCK; D. DAVIDSON;
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作者单位

MRC UK Mouse Genome Centre and Mammalian Genetics Unit, Harwell, Oxfordshire, England;

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原文格式 PDF
正文语种 eng
中图分类 Q8;
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1. Expanding the mammalian phenotype ontology to support automated exchange of high throughput mouse phenotyping data generated by large-scale mouse knockout screens [J] . Cynthia L Smith, Janan T Eppig Journal of Biomedical Semantics . 2015,第S1期

机译：扩展哺乳动物表型本体，以支持自动交换由大规模小鼠基因敲除屏幕产生的高通量小鼠表型数据
2. Phenotype ontologies for mouse and man: bridging the semantic gap [J] . Georgios V. Gkoutos, John M. Hancock, John P. Sundberg, Disease models & mechanisms: DMM . 2010,第5a6期

机译：鼠标和人的表型本体：弥合语义鸿沟
3. Practical application of ontologies to annotate and analyse large scale raw mouse phenotype data [J] . Tim Beck, Hugh Morgan, Andrew Blake, BMC Bioinformatics . 2009,第SUPPLEMENTa5期

机译：本体在注释和分析大规模原始小鼠表型数据中的实际应用
4. BUILDING MOUSE PHENOTYPE ONTOLOGIES [C] . G. V. GKOUTOS, E. C. J. GREEN, A.M. MALLON, Pacific symposium on biocomputing . 2003

机译：建立鼠标表型本体
5. Ontology-based Context in Visualizations to Facilitate Sensemaking: Case Studies of Phenotype Comparisons [D] . Glueck, Michael. 2018

机译：可视化中基于本体的上下文，以促进感官：表型比较的案例研究
6. Expanding the mammalian phenotype ontology to support automated exchange of high throughput mouse phenotyping data generated by large-scale mouse knockout screens [O] . Cynthia L Smith, Janan T Eppig 2015

机译：扩展哺乳动物表型本体以支持自动交换由大规模小鼠基因敲除屏幕产生的高通量小鼠表型数据
7. Building mouse phenotype ontologies [O] . G. V. Gkoutos, E. C. J. Green, A. M. Mallon, 2004

机译：建立小鼠表型本体

BUILDING MOUSE PHENOTYPE ONTOLOGIES

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