Identifying Conserved Discriminative Motifs

机译：识别保守的区分母题

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The identification of regulatory motifs underlying gene expression is a challenging problem, particularly in eukaryotes. An algorithm to identify statistically significant discriminative motifs that distinguish between gene expression clusters is presented. The predictive power of the identified motifs is assessed with a supervised Naive Bayes classifier. An information-theoretic feature selection criterion helps find the most informative motifs. Results on benchmark and real data demonstrate that our algorithm accurately identifies discriminative motifs. We show that the integration of comparative genomics information into the motif finding process significantly improves the discovery of discriminative motifs and overall classification accuracy.

机译：基因表达调控基序的鉴定是一个挑战性的问题，特别是在真核生物中。提出了一种算法，该算法可识别具有统计学意义的区分基元，以区分基因表达簇。使用监督的朴素贝叶斯分类器评估识别出的图案的预测能力。信息理论的特征选择标准有助于找到最有用的图案。基准数据和真实数据的结果表明，我们的算法可以准确识别出有区别的图案。我们表明，将比较基因组学信息整合到模体发现过程中，显着提高了判别性模体的发现和整体分类的准确性。

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来源
《Pattern Recognition in Bioinformatics》|2008年|334-348|共16页
会议地点 Melbourne(AU);Melbourne(AU)
作者
Jyotsna Kasturi; Raj Acharya; Ross Hardison;
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作者单位

Non-Clinical Biostatistics, Johnson Johnson Pharmaceutical Research Development, New Jersey Department of Computer Science and Engineering, Pennsylvania State University;

Department of Computer Science and Engineering, Pennsylvania State University;

Center for Comparative Genomics and Bioinformatics, Huck Institutes of Life Sciences Department of Biochemistry and Molecular Biology Pennsylvania State University;

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原文格式 PDF
正文语种 eng
中图分类生物工程学（生物技术）;
关键词
discriminative motifs; regulatory elements; comparative genomics; classification; Naive Bayes; mutual information;

机译：区分性图案；监管要素；比较基因组学；分类;朴素贝叶斯；共同信息;
入库时间 2022-08-26 13:51:20

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2. Identifying discriminative classification-based motifs in biological sequences. [J] . Vens C., Rosso M. N., Danchin E. G. J. Bioinformatics . 2011,第9期

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3. Identifying discriminative classification-based motifs in biological sequences [J] . Etienne G. J. Danchin Bioinformatics . 2011,第9期

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4. Identifying Conserved Discriminative Motifs [C] . Jyotsna Kasturi, Raj Acharya, Ross Hardison IAPR International Conference on Pattern Recognition in Bioinformatics . 2008

机译：识别保守的判别基序
5. Identification and characterization of a conserved soluble guanylate cyclase-like heme domain that discriminates between nitric oxide and oxygen. [D] . Karow, David Stanley. 2005

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6. Linear array of conserved sequence motifs to discriminate protein subfamilies: study on pyridine nucleotide-disulfide reductases [O] . César L Avila, Viviana A Rapisarda, Ricardo N Farías, 2007

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7. Identifying Conserved Discriminative Motifs [O] . Jyotsna Kasturi, Raj Acharya, Ross Hardison 2008

机译：识别保守的判别基序

Identifying Conserved Discriminative Motifs

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