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Photochemical inactivation of viruses by antibody conjugates of compounds generating singlet oxygen

机译：通过产生单线态氧的化合物的抗体缀合物对病毒进行光化学灭活

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Abstract: For the first time a method is proposed for targeted destruction of viral particles with a photoimmuno- toxin. The photoinununotoxin is a conjugate of antibodies and dimethoxy haematoporphyrin (a potent singlet oxygen generator), binding with the viral particle and upon illumination with visible light inactivating the virus by singlet oxygen. The method can be used to combat viral infection in humans and to prevent lysis of industrial micro-organisms by lysogenic bacteriophage strains. !9

机译：摘要：首次提出了一种用光免疫毒素靶向破坏病毒颗粒的方法。光致免疫毒素是抗体和二甲氧基血卟啉（一种有效的单线态氧产生剂）的结合物，与病毒颗粒结合，并在可见光照射下被单线态氧灭活。该方法可用于抵抗人类的病毒感染，并防止溶源性噬菌体菌株溶解工业微生物。！9

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来源
《Photodynamic Therapy of Cancer》|1993年|p.324-327|共4页
会议地点 Budapest(HU)
作者
Alexander P. Savitsky; Institute of Biochemistry; Moscow; Russia; Andrey I. Tourkin; Institute of Biochemistry; Moscow; Russia; Elena V. Tourkina; Institute of Biochemistry; Moscow; Russia; Tatyana V. Cherednikova; Institute of Biochemistry; Moscow; Russi;
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正文语种 eng
中图分类无线电电子学、电信技术;
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专利

1. Inactivation of enveloped viruses by singlet oxygen thermally generated from a polymeric naphthalene derivative. [J] . Kasermann F, Kempf C Antiviral Research . 1998,第1期

机译：由聚合萘衍生物热生成的单重态氧使包膜病毒失活。
2. Strategies for cleaner oxidations using photochemically generated singlet oxygen in supercritical carbon dioxide [J] . Xue Han, Richard A. Bourne, Martyn Poliakoff Green chemistry . 2009,第11期

机译：在超临界二氧化碳中使用光化学生成的单重态氧进行更清洁的氧化的策略
3. Inactivation of Escherichia coli and MS2 coliphage via singlet oxygen generated by homogeneous photosensitization [J] . Kim Taewan, Kim Hyung-Eun, Cho Jiyoon, The Korean journal of chemical engineering . 2019,第11期

机译：均相光敏化产生的单线态氧使大肠杆菌和MS2噬菌体失活
4. Photochemical inactivation of viruses by antibody conjugates of compounds generating singlet oxygen [C] . Alexander P. Savitsky, Andrey I. Tourkin, Elena V. Tourkina, Conference on photodynamic therapy of cancer . 1994

机译：通过化合物的抗体缀合物产生的光化学灭活，生成单线氧的抗体缀合物
5. MECHANISMS OF PHOTOOXIDATIONS: ELECTRON-TRANSFER TO SINGLET OXYGEN, SUBSTRATE ENHANCED INTERSYSTEM CROSSING AS A SOURCE OF SINGLET OXYGEN AND SINGLET OXYGEN-OLEFIN INTERACTIONS. [D] . MANRING, LEWIS EDWARD. 1982

机译：光氧化的机理：电子转移到单氧，基质增强的系统间交叉作为单氧的来源和单氧-烯烃相互作用。
6. Inactivation of Neurospora crassa conidia by singlet molecular oxygen generated by a photosensitized reaction. [O] . M Shimizu, T Egashira, U Takahama 1979

机译：通过光敏反应产生的单重态分子氧使神经孢霉的分生孢子失活。
7. Singlet oxygen treatment of tumor cells triggers extracellular singlet oxygen generation, catalase inactivation and reactivation of intercellular apoptosis-inducing signaling [O] . Riethmüller Michaela, Burger Nils, Bauer Georg 2015

机译：肿瘤细胞的单线态氧治疗可触发细胞外单线态氧的产生，过氧化氢酶的失活以及细胞间凋亡诱导信号的重新激活
8. Reactivity of Singlet Oxygen Toward Strained Substrates and Novel Non-Photochemical Method for Determination of Quenching Constants of Singlet Oxygen [R] . Turro, N. J., Chow, M. F., Kanfer, S., 1980

机译：单线态氧对应变基质的反应性和新型非光化学法测定单线态氧的猝灭常数

Photochemical inactivation of viruses by antibody conjugates of compounds generating singlet oxygen

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