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Immunopharmacology studies on photosensitizers used in photodynamic therapy

机译:光动力疗法中使用的光敏剂的免疫药理研究

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Abstract: Since immunity is important in the control of tumor growth and spreading, in our laboratory we examine the effect of photoactivated phthalocyanines on the immune compartment. Spleen hyperplasia as well as spleen and marrow hypercellularities were observed in mice bearing MS-2 fibrosarcoma treated at different times with Aluminum disulfonated Phthalocyanine and laser light. Results suggest a potential `tumor immunity' induced by PDT with photoactivated phthalocyanines and that the dyes used in PDT could play an immunopharmacological role in cancer treatment. !17
机译:摘要:由于免疫对于控制肿瘤的生长和扩散很重要,因此在我们的实验室中,我们研究了光活化酞菁对免疫区隔的影响。在不同时间用铝二磺化酞菁铝和激光处理的带有MS-2纤维肉瘤的小鼠中观察到脾脏增生以及脾脏和骨髓多细胞性。结果表明,PDT与光活化酞菁可诱导潜在的“肿瘤免疫”,并且PDT中使用的染料可在癌症治疗中发挥免疫药理作用。 !17

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