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首页> 外文学位 >The design and synthesis of chalcogenoxanthylium dyes for use as photosensitizers in photodynamic therapy (PDT) and photodynamic antimicrobial chemotherapy (PACT).
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The design and synthesis of chalcogenoxanthylium dyes for use as photosensitizers in photodynamic therapy (PDT) and photodynamic antimicrobial chemotherapy (PACT).

机译：设计和合成硫属黄原蒽染料，用作光动力疗法（PDT）和光动力抗菌化学疗法（PACT）中的光敏剂。

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摘要

Photodynamic therapy (PDT) is an FDA-approved treatment of various cancers in the United States. Photodynamic antimicrobial chemotherapy (PACT) is a technique that is now being reinvestigated as a cleansing technique for the blood supply that offers several advantages to currently used techniques. Each of these treatments uses a photosensitizer (drug) that localizes in or around the tumor or blood pathogen, light and molecular oxygen to cause cell or pathogen death selectively. The currently used photosensitizers in both treatments have certain limitations including: long-term skin photosensitivity, weak absorption of light, and absorption of light of too short a wavelength for optimal penetration in tissue and red blood cell damage. New photosensitizers that overcome these deficiencies would provide clinical options for the treatment of certain types of cancer and cleansing of the blood supply.;We have synthesized structural analogues of rhodamine 123 to address the limitations of rhodamine 123 as a photosensitizer. The photophysical properties of a series of chalcogenoxanthylium dyes were studied in which the substitution of sulfur, selenium and tellurium for oxygen in the xanthylium chromophore gave a proportionally larger increases in the quantum yield for the generation of singlet oxygen and these dyes now absorb light of longer wavelengths than rhodamine. This suggests that these novel analogues are potent photosensitizers. These new analogues have given information regarding the structural components necessary for the optimization of biological and light harvesting properties of these heavy-atom rhodamine photosensitizers for use in PDT and PACT.
机译：在美国，光动力疗法（PDT）是FDA批准的各种癌症的治疗方法。光动力抗菌化学疗法（PACT）是一项技术，目前正在重新研究，作为一种清洁血液供应的技术，它为当前使用的技术提供了许多优势。这些治疗方法中的每一种都使用光敏剂（药物），该光敏剂位于肿瘤或血液病原体中或周围，光和分子氧中或选择性地引起细胞或病原体死亡。目前在这两种治疗中使用的光敏剂都有一定的局限性，包括：长期皮肤光敏性，光吸收弱以及吸收波长太短的光而无法最佳地渗透到组织和红细胞中。克服这些缺陷的新型光敏剂将为某些类型的癌症的治疗和血液供应的清洁提供临床选择。我们已经合成了若丹明123的结构类似物，以解决若丹明123作为光敏剂的局限性。研究了一系列硫族氧杂蒽鎓染料的光物理性质，其中用硫，硒和碲替换黄蒽酮发色团中的氧会成比例地增加产生单线态氧的量子产率，这些染料现在吸收更长的光。波长比若丹明。这表明这些新颖的类似物是有效的光敏剂。这些新的类似物已提供了有关用于PDT和PACT的这些重原子若丹明光敏剂的生物学和光收集特性优化所必需的结构成分的信息。

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  • 作者

    Donnelly, David Joseph.;

  • 作者单位

    State University of New York at Buffalo.;

  • 授予单位 State University of New York at Buffalo.;
  • 学科 Chemistry Organic.
  • 学位 Ph.D.
  • 年度 2006
  • 页码 309 p.
  • 总页数 309
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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