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Direct phosphorescent detection of primary event of photodynamic action

机译：直接磷光检测光动力作用的主要事件

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Abstract: Highly phosphorescent photosensitizer Pd-tetra (o-methoxy-p-sulfo)phenyl porphyrin (Pd-MSPP) was used to follow primary events of photodynamic therapy (PDT). The sensitizer forms complexes with proteins in solutions and biosystems showing remarkable hypsochromic shifts of band and an increase of the quantum yield and life time of phosphorescence at the binding to proteins. It was found the life time of phosphorescence depends mostly on the energy of the lower triplet state of the sensitizer. Therefore photo-chemical quenching of the triplets by cell components is negligible. The quenching of the sensitizer triplets is observed in the presence of free oxygen in biosystems. The degree of quenching varies in dependence on the kind and state of the system and is governed by oxygen concentration and viscosity of the media. It was concluded that the singlet oxygen mechanism of photosensitization is operative only at the primary step of the process. !14

机译：摘要：使用高度磷光的光敏剂Pd-四（邻甲氧基-对-磺基）苯基卟啉（Pd-MSPP）跟踪光动力疗法（PDT）的主要事件。增敏剂在溶液和生物系统中与蛋白质形成复合物，显示出明显的谱带变色现象，并增加了与蛋白质结合时的量子产率和磷光寿命。发现磷光的寿命主要取决于敏化剂的较低三重态的能量。因此，通过细胞组分对三联体的光化学淬灭是微不足道的。在生物系统中存在游离氧的情况下观察到敏化剂三联体的淬灭。淬灭程度取决于系统的种类和状态，并受氧气浓度和介质粘度的控制。结论是光敏化的单线态氧机理仅在该过程的主要步骤起作用。！14

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来源
《Photodynamic Therapy of Cancer》|1993年|p.240-244|共5页
会议地点 Budapest(HU)
作者
Anatoly P. Losev; Institute of Molecular; Atomic Physics; Minsk; Belarus; Valentin N. Knukshto; Institute of Molecular; Atomic Physics; Minsk; Belarus; Ivan N. Zhuravkin; Research Institute of Oncology; Medical Radiology; Minsk; Belarus.;
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正文语种 eng
中图分类无线电电子学、电信技术;
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Direct phosphorescent detection of primary event of photodynamic action

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