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Antimicrobial and antiviral activity of porphyrin photosensitization

机译：卟啉光敏剂的抗菌和抗病毒活性

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Abstract: In order to photosensitize Gram (-) bacteria such as Pseudomonas aeuruginosa and Escherichia coli, we introduced the small peptide polymyxin-B nona-peptide (PBNP) which stimulated the translocation of porphyrin through the outer membrane of these bacteria and makes PDT possible. Gram negative cell killing by the use of PBNP and DP broadens the antibacterial spectrum of photodynamic inactivation and opens new horizons for this modality as a wide spectrum drug when antibiotic resistance is the main concern. Plasmidial and chromosomal DNA damage in S. aureus and E. coli cells was mediated by DP photosensitization. The major observation was the disappearance of the plasmid supercoiled fraction. The chromosomal DNA was also affected and its degradation products were detected after treatment. !35
机译：摘要：为了对绿脓杆菌和大肠杆菌等革兰氏（-）细菌进行光敏性，我们引入了小肽多粘菌素B壬肽（PBNP），该肽刺激卟啉通过这些细菌的外膜转运，从而使PDT成为可能。当主要考虑抗生素耐药性时，通过使用PBNP和DP杀死革兰氏阴性细胞可拓宽光动力灭活的抗菌谱，并为这种模式作为广谱药物开辟了新的前景。 DP光敏化介导了金黄色葡萄球菌和大肠杆菌细胞中的质粒和染色体DNA损伤。主要观察结果是质粒超螺旋级分的消失。处理后，染色体DNA也受到影响，并检测到其降解产物。 ！35

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