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首页> 外文会议>Photonic therapeutics and diagnostics VI >Clinical Studies of Frequency Domain Optical Coherence Tomography in the Coronary Arteries: The First 2000 Patients
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Clinical Studies of Frequency Domain Optical Coherence Tomography in the Coronary Arteries: The First 2000 Patients

机译：冠状动脉频域光学相干断层扫描的临床研究：首批2000例患者

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We report clinical study results of three-dimensional (3D) in vivo imaging of human coronary arteries using frequency domain optical coherence tomography (FD-OCT). At the time of this report, over 2000 patients in over 10 countries have been imaged using FD-OCT systems and disposable fiberoptic catheters developed by LightLab Imaging Inc. The first commercial versions of the systems were introduced in Europe in May 2009. The system operates at 50,000 axial lines/s, performing a 50 mm spiral pullback in 2.5 seconds with a rotational frame rate of 100 Hz. The commercial system employs a proprietary micro-cavity swept laser, allowing imaging of vessel diameters up to 10 mm. Data compiled from early studies indicate that FD-OCT is being used for post-intervention imaging of deployed coronary stents in over 40% of cases. High-resolution 3D imaging of stent geometry immediately following deployment enables detection of stent malapposition, which can increase the risk of thrombosis. Longer term follow-up imaging of stented vessels can detect thrombus formation, which can be treated pharmacologically, and excessive neointimal growth, which may require angioplasty or re-stenting. FD-OCT is also being used for pre-intervention imaging of stenotic lesions in about 60% of cases. Here FD-OCT is used to measure the minimμm lumen area and to identify calcified deposits, side branches, or other vascular structures that could interfere with the stenting procedure. Overall, FD-OCT continues to be adopted at an increasing rate and has provided interventional cardiologists with a powerful tool for pre- and post-intervention assessment of the coronary arteries.
机译：我们报告使用频域光学相干断层扫描（FD-OCT）对人类冠状动脉进行三维（3D）体内成像的临床研究结果。在撰写本报告时，已使用FD-OCT系统和LightLab Imaging Inc.开发的一次性光纤导管对10多个国家的2000多例患者进行了成像。该系统的首批商业版本于2009年5月在欧洲推出。以50,000轴/ s的速度，在2.5秒内以100 Hz的旋转帧速率执行50 mm螺旋拉回。该商业系统采用专有的微腔扫频激光器，可以对直径最大为10 mm的血管进行成像。早期研究收集的数据表明，FD-OCT在40％以上的病例中用于已部署的冠状动脉支架的介入后成像。展开后立即进行支架几何形状的高分辨率3D成像，可以检测出支架贴壁不良，从而增加了血栓形成的风险。支架血管的长期随访成像可以检测血栓形成（可以通过药理学治疗）以及过度的新内膜生长，这可能需要血管成形术或重新支架。在大约60％的病例中，FD-OCT也用于狭窄病变的介入前成像。此处，FD-OCT用于测量最小内腔面积，并识别可能干扰支架置入过程的钙化沉积物，侧支或其他血管结构。总体而言，FD-OCT继续以越来越高的速度被采用，并为介入心脏病学家提供了在冠状动脉介入之前和之后评估的强大工具。

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