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Comparison of frequency domain optical coherence tomography and quantitative coronary angiography for the assessment of coronary lesions

机译：频域光学相干断层扫描与定量冠状动脉造影在评估冠状动脉病变方面的比较

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摘要

Quantitative coronary angiography (QCA) has been used as a standard technique for the evaluation of coronary artery disease for many years. Intracoronary optical coherence tomography (OCT) offers higher resolution, faster image acquisition speeds and greater sensitivity than the intravascular ultrasound (IVUS). Recently developed frequency domain OCT (FD-OCT) systems overcome many technical limitations of conventional time domain OCT systems (TD-OCT). The main objective of this study was to compare the FD-OCT and QCA measurements for the assessment of coronary lesions. A total of 21 stenoses in 18 patients were analysed using QCA and FD-OCT. The average minimum lumen diameter (MLD) and percent lumen area stenosis (%AS) by QCA were 1.52±0.44 mm and 68±9% respectively. The average MLD and %AS by FD-OCT were 1.32±0.38 mm and 63±14% respectively. There was a moderate but significant correlation between QCA and FD-OCT measured MLD (r = 0.5, p ＜ 0.01) and %AS (r = 0.56, p ＜ 0.01). Bland-Altman analysis showed that the mean differences between the QCA and FD-OCT measurements were 0.18±0.81 (limits of agreement: -0.63 to 0.99) for MLD and 4.4±22.8 (limits of agreement: -18.4 to 27.2) for %AS. The root mean square error (RMSE) between the QCA and FD-OCT measured MLD and %AS was ±0.44 mm and ±12.1% respectively.
机译：多年以来，定量冠状动脉造影（QCA）已被用作评估冠状动脉疾病的标准技术。与血管内超声（IVUS）相比，冠状动脉内光学相干断层扫描（OCT）提供更高的分辨率，更快的图像采集速度和更高的灵敏度。最近开发的频域OCT（FD-OCT）系统克服了常规时域OCT系统（TD-OCT）的许多技术限制。这项研究的主要目的是比较FD-OCT和QCA测量对冠状动脉病变的评估。使用QCA和FD-OCT分析了18例患者中总共21例狭窄。 QCA的平均最小管腔直径（MLD）和管腔面积狭窄百分比（％AS）分别为1.52±0.44 mm和68±9％。 FD-OCT的平均MLD和％AS分别为1.32±0.38 mm和63±14％。 QCA和FD-OCT测得的MLD（r = 0.5，p ＜0.01）和％AS（r = 0.56，p ＜0.01）之间存在中等但显着的相关性。 Bland-Altman分析显示，MLD的QCA和FD-OCT测量值之间的平均差为0.18±0.81（一致极限：-0.63至0.99），％AS为4.4±22.8（一致极限：-18.4至27.2） 。 QCA和FD-OCT测得的MLD和％AS的均方根误差（RMSE）分别为±0.44 mm和±12.1％。

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  • 来源
    《Photonic therapeutics and diagnostics X》|2014年|89263M.1-89263M.5|共5页
  • 会议地点 San Francisco CA(US)
  • 作者

    Haroon Zafar; Faisal Sharif; Martin. J. Leahy;

  • 作者单位

    Tissue Optics Microcirculation Imaging Facility, National University of Ireland, Galway, National Biophotonics Imaging Platform, Ireland;

    Department of Cardiology, University Hospital Galway, Ireland, FIRB Clinical Research Facility, Galway, Ireland, Degenerative Medicine Institute, National University of Ireland, Galway, Bio Innovate, Ireland;

    Tissue Optics Microcirculation Imaging Facility, National University of Ireland, Galway, National Biophotonics Imaging Platform, Ireland, Royal College of Surgeons, Dublin, Ireland;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Intracoronary optical coherence tomography; angiography; coronary lesions;

    机译：冠状动脉内光学相干断层扫描；血管造影冠状动脉病变;

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