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Coronary Artery Plaque Assessment with Fast Switched Dual Energy X-Ray Computed Tomography Angiography.

机译：快速切换双能X射线计算机断层扫描血管造影术评估冠状动脉斑块。

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Coronary computed tomography angiography (CTA) has a high negative predictive value for ruling out coronary artery disease with non-invasive evaluation of the coronary arteries. My work has attempted to provide metrics that could increase the positive predictive value of coronary CTA through the use of dual energy CTA imaging. After developing an algorithm for obtaining calcium scores from a CTA exam, a dual energy CTA exam was performed on patients at dose levels equivalent to levels for single energy CTA with a calcium scoring exam. Calcium Agatston scores obtained from the dual energy CTA exam were within +/-11% of scores obtained with conventional calcium scoring exams. In the presence of highly attenuating coronary calcium plaques, the virtual non-calcium images obtained with dual energy CTA were able to successfully measure percent coronary stenosis within 5% of known stenosis values, which is not possible with single energy CTA images due to the presence of the calcium blooming artifact. After fabricating an anthropomorphic beating heart phantom with coronary plaques, characterization of soft plaque vulnerability to rupture or erosion was demonstrated with measurements of the distance from soft plaque to aortic ostium, percent stenosis, and percent lipid volume in soft plaque. A classification model was developed, with training data from the beating heart phantom and plaques, which utilized support vector machines to classify coronary soft plaque pixels as lipid or fibrous. Lipid versus fibrous classification with single energy CTA images exhibited a 17% error while dual energy CTA images in the classification model developed here only exhibited a 4% error. Combining the calcium blooming correction and the percent lipid volume methods developed in this work will provide physicians with metrics for increasing the positive predictive value of coronary CTA as well as expanding the use of coronary CTA to patients with highly attenuating calcium plaques.

机译：冠状动脉计算机断层造影血管造影（CTA）对于排除冠状动脉的非侵入性评估对排除冠状动脉疾病具有很高的阴性预测价值。我的工作试图提供可通过使用双能CTA成像增加冠状动脉CTA阳性预测价值的指标。在开发了从CTA考试中获取钙得分的算法后，对患者进行了双能量CTA考试，其剂量水平与通过钙评分检查获得的单能量CTA的水平相当。从双能CTA考试获得的钙Agatston评分在常规钙评分考试获得的评分的+/- 11％之内。在高度衰减的冠状动脉钙斑块存在下，通过双能CTA获得的虚拟非钙图像能够成功测量冠状动脉狭窄百分比在已知狭窄值的5％以内，这是单能量CTA图像无法实现的。钙开花神器。在制作出具有冠状斑块的拟人跳动心脏幻象后，通过测量从软斑块到主动脉口的距离，狭窄百分比和软斑块中脂质体积的百分比，证明了软斑块容易破裂或糜烂。利用来自跳动的心脏幻象和斑块的训练数据，开发了分类模型，该模型利用支持向量机将冠状软斑像素分类为脂质或纤维状。用单能CTA图像进行的脂质与纤维分类显示出17％的误差，而在此处开发的分类模型中的双能CTA图像仅显示4％的误差。结合这项工作中开发的钙晕染校正和脂质体积百分比方法，将为医师提供增加冠状动脉CTA阳性预测价值以及将冠状动脉CTA的用途扩展至钙化程度高度减轻的患者的指标。

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作者
Boltz, Thomas.;
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Arizona State University.;

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授予单位 Arizona State University.;
学科 Engineering Biomedical.;Health Sciences Radiology.
学位 Ph.D.
年度 2013
页码 105 p.
总页数 105
原文格式 PDF
正文语种 eng
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专利

1. Reduction of Coronary Motion Artifacts in Prospectively Electrocardiography-Gated Coronary Computed Tomography Angiography Using Monochromatic Imaging at Various Energy Levels in Combination With a Motion Correction Algorithm on Single-Source Fast Tube Voltage Switching Dual-Energy Computed Tomography A Phantom Experiment [J] . Machida Haruhiko, Fukui Rika, Gao Jianbo, Investigative radiology . 2016,第8期

机译：在单能快速管电压切换双能计算机断层扫描上使用各种能量水平的单色成像和运动校正算法，减少前瞻性心电门控的冠状动脉计算机断层扫描血管造影中的冠状动脉运动伪影
2. Potential of dual-energy computed tomography to characterize atherosclerotic plaque: ex vivo assessment of human coronary arteries in comparison to histology. [J] . Barreto M, Schoenhagen P, Nair A Journal of cardiovascular computed tomography . 2008,第4期

机译：双能计算机断层扫描技术表征动脉粥样硬化斑块的潜力：与组织学相比，人冠状动脉的离体评估。
3. Accuracy of Quantification of Iodine and Hounsfield Unit Values on Virtual Monochromatic Imaging Using Dual-Energy Computed Tomography: Comparison of Dual-Layer Computed Tomography With Fast Kilovolt-Switching Computed Tomography [J] . Washio Hayate, Ohira Shingo, Karino Tsukasa, Journal of computer assisted tomography . 2018,第6期

机译：使用双能计算机断层扫描的虚拟单色成像量化量化的准确性：用快速千伏切换计算机断层扫描的双层计算断层扫描的比较
4. Initial Use of Fast Switched Dual Energy CT for Coronary Artery Disease [C] . William Pavlicek, Prasad Panse, Amy Hara, Conference on physics of medical imaging . 2010

机译：快速开关双能CT在冠状动脉疾病中的初步使用
5. Application of dual-energy computed tomography to the evaluation of coronary atherosclerotic plaque. [D] . Barreto, Mitya Maria. 2010

机译：双能计算机断层扫描在评估冠状动脉粥样硬化斑块中的应用。
6. Dual Energy Computed Tomography of Internal Carotid Artery: A Modified Dual-Energy Algorithm for Calcified Plaque Removal Compared With Digital Subtraction Angiography [O] . Hongying Qu, Yongan Gao, Meiling Li, 2020

机译：内部颈动脉的双能量计算断层扫描：与数字减法血管造影相比用于钙化斑块去除的改良双能算法
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机译：在使用新的扩张型心肌病的患者缓和EPOSTERS1385Longitudinal应变评估加速DENSE sequence1407Simultaneous T1和T2与CABIRIA心脏定量：在4维流动的加速算法初始临床experience1423Head对头比较CMR1502Left心室功能和尺寸由混合心脏正电子发射断层摄影术评价 - 磁性共振：由两个modalities1510Left庭派生左室射血分数和心室体积的个体间的比较，在1.5和3特斯拉评估心血管磁共振 - 免费的年龄和性别effects1514Comparison呼吸心脏MRI径向技术标准的多屏气电影SSFP CMR技术的LV卷和Function1536Self-导航自由呼吸各向同性3D整个心脏相位敏感反转恢复磁共振导航仪没有检测右Ventricu心肌infarction1547Assessment的评估拉尔菌株使用心肌变形恢复半自动技术：初步经验和正常Values1586Tissue跟踪心肌变形分析和预测左室重构急性心肌infarction1589Investigating策略优化31P MRS临床心脏在3T：初始Results1620Quantitative标准的先天缺失的诊断心包心脏磁Resonance1632Widespread组织损伤急性心肌梗死时：证据先进CMR relaxometry1322Computed CT冠状动脉成像与压力心脏磁共振对症的管理吻合血管患者：成本效益研究（战略研究）1339Comparison低与高剂量钆布醇在1.5特斯拉晚钆增强成像的临床可行性，在中间型地贫心脏并发症的预测study1347Multi参数心脏核磁共振的前瞻性德穆尔心血管磁共振的ticenter Study1461Prognostic价值衍生心肌纤维化指标在住院的急性期CMR的心脏移植recipients1523The作用：改变基于CMR-paradigms1542Preoperative比分预测缺血性心脏衰竭patients1555Excellent响应速度外科左心室重建心脏再同步化后心室反应治疗与磁共振imaging1626The ECG导引作为心脏磁共振成像致心律失常性基板的在ST段抬高心肌infarction1340Pathological在风险评估经历在3.0T CMR T1映射的室性早搏contractions1649Comparison和血管造影APPROACH分数区域消融患者的预测左束支传导疾病的患者与非缺血性心肌病相关因素：心血管磁共振study1342Myocardial重塑和纤维化nonischaemic扩张型心肌病：在从在由心血管磁性resonance1622Persistent心肌炎症评估肥厚型心肌病的纤维化和收缩功能障碍之间心血管磁性resonance1411The协会由于心肌内出血景点在再灌注STEMI为先导，以不利的LV重塑 - 从低的多参数mapping1566Semiquantitative分析和高的b值DWI的见解为在心脏MRI检测冠状动脉疾病急性myocarditis1567Value在结节性硬化症complex1578Papillary肌肉初诊收缩期Dysfunction1570Usefulness心脏磁共振检测心肌水肿提供进一步的深入了解肥大心脏：心血管磁共振study1627Diagnostic和CMR定时的临床意义（早期与晚）患者肌钙蛋白阳性的急性冠脉综合征和通畅的冠状动脉：表1。

Coronary Artery Plaque Assessment with Fast Switched Dual Energy X-Ray Computed Tomography Angiography.

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