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首页> 外文会议>Photonic therapeutics and diagnostics X >Attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopic analysis of regenerated bone
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Attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopic analysis of regenerated bone

机译：再生骨的衰减全反射傅里叶变换红外光谱（ATR-FTIR）

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摘要

The cutting of bone is routinely required in medical procedures, especially in dental applications. In such cases, bone regeneration and new bone quality can determine the success of the treatment. This study investigated the main spectral differences of undamaged and healed bone using the ATR-FTIR spectroscopy technique. Three rabbits were submitted to a surgical procedure; a small piece of bone (3×3 mm~2) was removed from both sides of their jaws using a high speed drill. After 15 days, the rabbits were euthanized and the jaws were removed. A bone slice was cut from each side of the jaw containing regions of undamaged and newly formed bone, resulting in six samples which were polished for spectroscopic comparison. The samples were analyzed by FTIR spectroscopy using a diamond ATR accessory. Spectral characteristics were compared and particular attention was paid to the proportion of phosphate to amide 1 bands and the width of the phosphate band. The results show that the ratio of phosphate to amide I is smaller in new bone tissue than in the undamaged bone, indicating a higher organic content in the newly formed bone. The analysis of the width of the phosphate band suggests a crystallinity difference between both tissues, since the width was higher in the new bone than in the natural bone. These results suggest that the differences observed in bone aging processes by FTIR spectroscopic can be applied to the study of healing processes.
机译：在医疗程序中，特别是在牙科应用中，通常需要切割骨头。在这种情况下，骨再生和新骨质量可以决定治疗的成功。这项研究使用ATR-FTIR光谱技术研究了未受损和已愈合骨的主要光谱差异。三只兔子接受了外科手术。用高速钻从颌骨的两侧切除一小块骨头（3×3 mm〜2）。 15天后，对兔子实施安乐死并取下颌。从颌骨的每一侧切下一个骨切片，其中包含未损坏和新形成的骨骼区域，得到六个样品，将其抛光以进行光谱比较。使用金刚石ATR附件通过FTIR光谱分析样品。比较了光谱特性，并特别注意了磷酸盐与酰胺1谱带的比例和磷酸盐带的宽度。结果表明，新骨组织中磷酸盐与酰胺I的比例比未受损骨中的比例小，表明新形成的骨中有机物含量较高。磷酸盐带宽度的分析表明两个组织之间的结晶度差异，因为新骨的宽度比天然骨的宽度高。这些结果表明，通过FTIR光谱在骨老化过程中观察到的差异可用于研究愈合过程。

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  • 来源
    《Photonic therapeutics and diagnostics X》|2014年|892641.1-892641.6|共6页
  • 会议地点 San Francisco CA(US)
  • 作者

    Carolina Benetti; Sergei G. Kazarian; Marco A. V. Alves; Alberto Blay; Luciana Correa; Denise M. Zezell;

  • 作者单位

    Instituto de Pesquisa Energeticas e Nucleares IPEN - CNEN/SP, Av. Lineu Prestes 2242 - Sao Paulo/SP, Brazil;

    Department of Chemical Engineering, Imperial College London, SW7 2AZ, UK;

    Department of Oral and Maxillofacial Surgery, Division of Maxillofacial Traumatology, School of Dentistry, USP, Sao Paulo-SP, Brazil;

    Department of Oral and Maxillofacial Surgery, Division of Maxillofacial Traumatology, School of Dentistry, USP, Sao Paulo-SP, Brazil;

    Department of Oral and Maxillofacial Surgery, Division of Maxillofacial Traumatology, School of Dentistry, USP, Sao Paulo-SP, Brazil;

    Instituto de Pesquisa Energeticas e Nucleares IPEN - CNEN/SP, Av. Lineu Prestes 2242 - Sao Paulo/SP, Brazil;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    FTIR; bone; laser; healing processes;

    机译：FTIR;骨;激光;愈合过程;

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