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首页> 外文会议>Photonic therapeutics and diagnostics XII >Redox subpopulations and the risk of cancer progression: A new method for characterizing redox heterogeneity
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Redox subpopulations and the risk of cancer progression: A new method for characterizing redox heterogeneity

机译：氧化还原亚群和癌症进展风险：表征氧化还原异质性的新方法

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摘要

It has been shown that a malignant tumor is akin to a complex organ comprising of various cell populations including tumor cells that are genetically, metabolically and functionally different. Our redox imaging data have demonstrated intra-tumor redox heterogeneity in all mouse xenografts derived from human melanomas, breast, prostate, and colon cancers. Based on the signals of NADH and oxidized flavoproteins (Fp, including flavin adenine dinucleotide (FAD)) and their ratio, i.e., the redox ratio, which is an indicator of mitochondrial metabolic status, we have discovered several distinct redox subpopulations in xenografts of breast tumors potentially recapitulating functional/metabolic heterogeneity within the tumor. Furthermore, xenografts of breast tumors with higher metastatic potential tend to have a redox subpopulation whose redox ratio is significantly different from that of tumors with lower metastatic potential and usually have a bi-modal distribution of the redox ratio. The redox subpopulations from human breast cancer samples can also be very complex with multiple subpopulations as determined by fitting the redox ratio histograms with multi-Gaussian functions. In this report, we present a new method for identifying the redox subpopulations within individual breast tumor xenografts and human breast tissues, which may be used to differentiate between breast cancer and normal tissue and among breast cancer with different risks of progression.
机译：已经表明，恶性肿瘤类似于由多种细胞群组成的复杂器官，所述多种细胞群包括遗传，代谢和功能上不同的肿瘤细胞。我们的氧化还原成像数据已证明，在源自人黑素瘤，乳腺癌，前列腺癌和结肠癌的所有小鼠异种移植物中，肿瘤内氧化还原异质性。根据NADH和氧化的黄素蛋白（Fp，包括黄素腺嘌呤二核苷酸（FAD））的信号及其比率，即氧化还原比，它是线粒体代谢状态的指标，我们发现了乳房异种移植物中的几个不同的氧化还原亚群肿瘤潜在地概括了肿瘤内的功能/代谢异质性。此外，具有较高转移潜能的乳腺肿瘤的异种移植物倾向于具有氧化还原亚群，其氧化还原比与具有较低转移潜能的肿瘤的氧化还原比显着不同，并且通常具有氧化还原比的双峰分布。人类乳腺癌样品的氧化还原亚群也可能非常复杂，具有多个亚群，这是通过将氧化还原比直方图与多高斯函数拟合来确定的。在本报告中，我们提出了一种新的方法，用于识别单个乳腺肿瘤异种移植物和人乳腺组织内的氧化还原亚群，可用于区分乳腺癌和正常组织以及具有不同进展风险的乳腺癌。

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  • 来源
    《Photonic therapeutics and diagnostics XII》|2016年|96893Z.1-96893Z.7|共7页
  • 会议地点 San Francisco CA(US)
  • 作者

    He N. Xu; Lin Z. Li;

  • 作者单位

    Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA,Britton Chance Laboratory of Redox Imaging, Johnson Research Foundation, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;

    Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA,Britton Chance Laboratory of Redox Imaging, Johnson Research Foundation, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA,Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA,Institute of Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    intratumor metabolic heterogeneity; mitochondrial NADH and flavoproteins including FAD; redox ratio; autofluorescence imaging; invasive and metastatic potential; breast cancer patients; clinical biopsy; mouse xenografts;

    机译：肿瘤内代谢异质性线粒体NADH和黄素蛋白，包括FAD；氧化还原比自体荧光成像侵袭和转移潜能；乳腺癌患者；临床活检；小鼠异种移植;

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