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首页> 外文期刊>Cancer and Metastasis Reviews >p66Shc--a longevity redox protein in human prostate cancer progression and metastasis : p66Shc in cancer progression and metastasis.
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p66Shc--a longevity redox protein in human prostate cancer progression and metastasis : p66Shc in cancer progression and metastasis.

机译：p66Shc-人类前列腺癌进展和转移中的长寿氧化还原蛋白：p66Shc在癌症进展和转移中。

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摘要

p66Shc, a 66 kDa proto-oncogene Src homologous-collagen homologue (Shc) adaptor protein, is classically known in mediating receptor tyrosine kinase signaling and recently identified as a sensor to oxidative stress-induced apoptosis and as a longevity protein in mammals. The expression of p66Shc is decreased in mice and increased in human fibroblasts upon aging and in aging-related diseases, including prostate cancer. p66Shc protein level correlates with the proliferation of several carcinoma cells and can be regulated by steroid hormones. Recent advances point that p66Shc protein plays a role in mediating cross-talk between steroid hormones and redox signals by serving as a common convergence point in signaling pathways on cell proliferation and apoptosis. This article first reviews the unique function of p66Shc protein in regulating oxidative stress-induced apoptosis. Subsequently, we discuss its novel role in androgen-regulated prostate cancer cell proliferation and metastasis and the mechanism by which it mediates androgen action via the redox signaling pathway. The data together indicate that p66Shc might be a useful biomarker for the prognosis of prostate cancer and serve as an effective target for its cancer treatment.
机译：p66Shc是一种66 kDa的原癌基因Src同源胶原同系物（Shc）衔接蛋白，在介导受体酪氨酸激酶信号传导方面是众所周知的，最近被确定为氧化应激诱导的细胞凋亡的传感器和哺乳动物的长寿蛋白。 p66Shc的表达在小鼠中降低，而在人成纤维细胞中则随着年龄的增长以及与衰老相关的疾病（包括前列腺癌）的表达增加。 p66Shc蛋白水平与几种癌细胞的增殖有关，并且可以由类固醇激素调节。最近的进展表明，p66Shc蛋白通过充当细胞增殖和凋亡的信号传导途径中的共同收敛点，在介导类固醇激素和氧化还原信号之间的相互作用中发挥作用。本文首先回顾了p66Shc蛋白在调节氧化应激诱导的细胞凋亡中的独特功能。随后，我们讨论了其在雄激素调节的前列腺癌细胞的增殖和转移中的新作用，以及其通过氧化还原信号途径介导雄激素作用的机制。数据一起表明p66Shc可能是前列腺癌预后的有用生物标志物，并成为其癌症治疗的有效靶标。

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