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首页> 外文会议>Photons Plus Ultrasound: Imaging and Sensing 2006; Progress in Biomedical Optics and Imaging; vol.7, no.9 >Photoacoustic molecular imaging of small animals in vivo
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Photoacoustic molecular imaging of small animals in vivo

机译：小动物体内的光声分子成像

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Molecular imaging is a newly emerging field in which the modern tools of molecular and cell biology have been married to state-of-the-art technologies for noninvasive imaging. The study of molecular imaging will lead to better methods for understanding biological processes as well as diagnosing and managing disease. Here we present noninvasive in vivo spectroscopic photoacoustic tomography (PAT)-based molecular imaging of αvβ3 integrin in a nude mouse U87 brain tumor. PAT combines high optical absorption contrast and high ultrasonic resolution by employing short laser pulses to generate acoustic waves in biological tissues through thermoelastic expansion. Spectroscopic PAT-based molecular imaging offers the separation of the contributions from different absorbers based on the differences in optical absorption spectra among those absorbers. In our case, in the near infrared (NIR) range, oxy-heamoglobin (O_2Hb), deoxy-heamoglobin (HHb) and the injected αvβ3-targeted peptide-ICG conjugated NIR fluorescent contrast agent are the three main absorbers. Therefore, with the excitation by multiple wavelength laser pulses, spectroscopic PAT-based molecular imaging not only provides the level of the contrast agent accumulation in the U87 glioblastoma tumor, which is related to the metabolism and angiogenesis of the tumor, but also offers the information on tumor angiogenesis and tumor hypoxia.
机译：分子成像是一个新兴领域，分子和细胞生物学的现代工具已经与无创成像的最新技术结合在一起。分子影像学的研究将为理解生物学过程以及诊断和治疗疾病提供更好的方法。在这里，我们介绍了裸鼠U87脑肿瘤中基于αvβ3整联蛋白的无创体内光谱光声层析成像（PAT）分子成像。 PAT通过使用短激光脉冲通过热弹性膨胀在生物组织中产生声波，将高光学吸收对比度和高超声分辨率结合在一起。基于光谱PAT的分子成像可根据不同吸收体之间光吸收谱的差异，将不同吸收体的贡献区分开来。在我们的情况下，在近红外（NIR）范围内，氧合血红蛋白（O_2Hb），脱氧血红蛋白（HHb）和注射的αvβ3靶向肽-ICG共轭NIR荧光造影剂是三个主要吸收剂。因此，在多波长激光脉冲的激发下，基于光谱的基于PAT的分子成像不仅可以提供U87胶质母细胞瘤肿瘤中造影剂的积累水平，这与肿瘤的代谢和血管生成有关，而且还可以提供信息对肿瘤血管生成和肿瘤缺氧。

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