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首页> 外文会议>Photons Plus Ultrasound: Imaging and Sensing 2006; Progress in Biomedical Optics and Imaging; vol.7, no.9 >Photoacoustics of individual live cells and particles
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Photoacoustics of individual live cells and particles

机译：单个活细胞和颗粒的光声

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摘要

The photoacoustic (PA) technique has been employed to a number of new biomedical applications based of highly-sensitive detection of laser-induced acoustic waves from individual live cells and single absorbing micro-particles or clusters of nanoparticles. These applications involve both linear and non-linear thermoacoustic phenomena initiated by focused nanosecond single laser pulse and detected with a fast PZT-ceramic acoustic transducer. Particularly, we present the following experimental results: 1) monitoring of linear and non-linear PA responses from red blood cells in suspensions in vitro; 2) detection of PA responses from breast cancer cell targeted with gold nanoparticles; 3) PA study of linear and non-linear interaction of laser with colored polystyrene micro-particles as model single absorbers; 4) monitoring of PA responses from moving absorbers in flow in vitro (PA flow cytometry in vitro); 5) recording of PA responses from blood flow in vivo on rat mesentery as animal model (PA flow cytometery in vivo); and 6) monitoring of sedimentation kinetics of particles and cells. The obtained results demonstrate the high sensitivity, low background, simple detection principle, easy data acquisition, and straightforward interpretation of the PA data.
机译：光声（PA）技术已被用于许多新的生物医学应用中，这些应用基于对来自单个活细胞和单个吸收性微粒或纳米粒子簇的激光感应声波的高灵敏度检测。这些应用涉及线性和非线性热声现象，这些现象由聚焦的纳秒单个激光脉冲引发，并由快速的PZT-陶瓷声换能器检测到。特别是，我们提供以下实验结果：1）体外监测悬浮液中红细胞的线性和非线性PA反应； 2）从金纳米颗粒靶向的乳腺癌细胞中检测PA反应； 3）PA与彩色聚苯乙烯微粒作为模型单吸收体的激光的线性和非线性相互作用研究； 4）监测体外流动的吸收剂对PA的反应（体外PA流式细胞仪）； 5）以动物模型记录大鼠肠系膜上来自体内血流的PA应答（体内PA流式细胞术）； 6）监测颗粒和细胞的沉降动力学。获得的结果表明，该方法具有高灵敏度，低背景，简单的检测原理，容易的数据采集以及对PA数据的直接解释。

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