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首页> 外文会议>Photons Plus Ultrasound: Imaging and Sensing 2006; Progress in Biomedical Optics and Imaging; vol.7, no.9 >Single-energy Wash-in Photoacoustic Blood Flow Measurements Using Shape Transitions of Gold Nanorods
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Single-energy Wash-in Photoacoustic Blood Flow Measurements Using Shape Transitions of Gold Nanorods

机译：使用金纳米棒的形状转变的单能量冲洗光声血流量测量。

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A time-intensity based method for photoacoustic blood flow measurements was proposed in last year's meeting. The method made use of the strong photoacoustic response of gold nanospheres and the "wash-out" characteristics of the nanospheres were analyzed. In this paper, we develop a new quantitative technique for measuring blood flows based on the "wash-in" characteristics of the nanoparticles. In particular, the technique makes use of the shape dependence of the optical absorption of gold nanorods (i.e., cylindrical nanoparticles) and the transitions in their shape induced by pulsed laser irradiation. The photon-induced shape transition of gold nanorods involves mainly a rod-to-sphere conversion and a shift in the peak optical absorption wavelength. The application of a series of laser pulses with the same laser energy will induce shape changes in gold nanorods as they flow through a region of interest, with quantitative flow information being derived from the photoacoustic signals from the irradiated gold nanorods measured as a function of time. To demonstrate the feasibility of the technique, an Nd:YAG laser operating at 1064 nm was used for irradiation and a ultrasonic transducer with a center frequency of 1 MHz was used for acoustic detection. Excellent agreement between the measured velocities and the actual velocities was demonstrated, with a linear regression correlation coefficient higher than 0.9. Compared to the wash-out analysis, the wash-in analysis is more suitable for measuring flows in microcirculation.
机译：去年的会议上提出了一种基于时间强度的光声血流测量方法。该方法利用了金纳米球的强光声响应，并分析了纳米球的“冲洗”特性。在本文中，我们开发了一种新的定量技术，可基于纳米颗粒的“洗入”特性测量血流量。特别地，该技术利用了金纳米棒（即，圆柱形纳米颗粒）的光吸收的形状依赖性以及由脉冲激光辐射引起的其形状的转变。金纳米棒的光子诱导形状转变主要涉及棒到球的转换以及峰值光吸收波长的偏移。一系列具有相同激光能量的激光脉冲的施加会在金纳米棒流过感兴趣区域时引起金纳米棒的形状变化，而定量的流量信息则是根据时间测得的，来自辐照的金纳米棒的光声信号得出的。为了证明该技术的可行性，使用工作在1064 nm的Nd：YAG激光器进行辐照，并使用中心频率为1 MHz的超声换能器进行声学检测。测得的速度与实际速度之间表现出极好的一致性，线性回归相关系数高于0.9。与冲洗分析相比，冲洗分析更适合于测量微循环中的流量。

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