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首页> 外文会议>Photons Plus Ultrasound: Imaging and Sensing 2007; Progress in Biomedical Optics and Imaging; vol.8 no.14; Proceedings of SPIE-The International Society for Optical Engineering; vol.6437 >Detection and noninvasive diagnostics of breast cancer with two-color laser optoacoustic imaging system
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Detection and noninvasive diagnostics of breast cancer with two-color laser optoacoustic imaging system

机译：两色激光光声成像系统对乳腺癌的检测和无创诊断

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摘要

We have designed, fabricated and tested a new laser optoacoustic imaging system (LOIS-64/16) for quantitative optoacoustic tomography of breast cancer. The system was designed to create a single slice of an optoacoustic image of the breast with 64 ultrawide band acoustic transducers. Other 16 transducers on the back of the acoustic probe were used to reconstruct the light distribution inside the breast. The system resolution was at least 0.5 mm for high-aspect-ratio objects. Maximum system sensitivity was 4.8 mV/Pa and the RMS noise of 3.1 mV, which allowed imaging of small (less than 1 cm) tumors at depths over 3 cm. The directivity of the optoacoustic transducers used in LOIS-64/16 assured that the signal detection was better than 70% of the maximum for about 75% of the imaging slice and reduced quickly for signals coming from out of the imaging slice. Implemented signal processing allowed significant reduction of the low-frequency acoustic noise and localizing the small OA signals. The system was able to differentiate phantoms mimicking tumors and malformations visualized in clinics based on the contrast and morphology of their images obtained at 1064 nm and 757 nm.
机译：我们已经设计，制造和测试了一种新的激光光声成像系统（LOIS-64 / 16），用于乳腺癌的定量光声层析成像。该系统旨在使用64个超宽带声换能器创建乳房的光声图像的单个切片。声学探头背面的其他16个传感器用于重建乳房内部的光分布。对于高纵横比的对象，系统分辨率至少为0.5 mm。最大系统灵敏度为4.8 mV / Pa，RMS噪声为3.1 mV，可对3 cm以上深度的小（小于1 cm）肿瘤进行成像。 LOIS-64 / 16中使用的光声换能器的方向性确保了在大约75％的成像切片中，信号检测优于最大值的70％，并且对于来自成像切片的信号迅速减少。实施的信号处理可以显着降低低频声噪声，并定位较小的OA信号。该系统能够根据在1064 nm和757 nm处获得的图像的对比度和形态来区分模拟在临床中可视化的肿瘤和畸形的幻像。

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