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Experimental study and first clinical results with a cooled a

机译：降温药的实验研究和首次临床结果

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Abstract: Laser-induced interstitial thermotherapy has proven to be an effective method for the treatment of different types of tumors. Until now the attainable coagulation volume was limited by the maximum applicable energy. The limiting factor is the high tissue temperatures around the applicator which may cause applicator damage. Consequently an internally cooled catheter system has been developed in order to reduce the temperature of the applicator surface and therefore enable the application of higher laser powers. The optimal treatment parameters for the Nd:YAG laser were determined on the basis of computer simulations and in vitro studies with porcine liver. Following these experimental studies, 72 patients with liver metastases were treated with the cooled applicator system. The applicator position and the resulting tissue damage were verified using the MRI on- line monitoring system with a FLASH-2D sequence. The optimal treatment parameters were found to be 25 watts for an exposure time of 20 minutes, resulting in coagulated volumes of up to 20 cm$+3$/. The experimental and clinical results proved that the combination of a scattering laser applicator with an internally flushed catheter enables a significant increase in the coagulation volume.!8
机译：摘要：激光诱导间质热疗法已被证明是治疗不同类型肿瘤的有效方法。迄今为止，可达到的凝结量受最大可利用能量的限制。限制因素是涂抹器周围的高温组织温度，这可能会导致涂抹器损坏。因此，已经开发出内部冷却的导管系统，以降低施加器表面的温度，并因此能够施加更高的激光功率。基于计算机模拟和猪肝的体外研究，确定了Nd：YAG激光的最佳治疗参数。在进行了这些实验研究之后，使用冷却的涂药器系统治疗了72例肝转移患者。使用带有FLASH-2D序列的MRI在线监测系统，可以验证施药器的位置以及由此引起的组织损伤。发现最佳的处理参数为25瓦，暴露时间为20分钟，从而导致凝结的体积高达20 cm + 3。实验和临床结果证明，散射激光施加器与内部冲洗导管的组合可显着增加凝血体积。8

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