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An engineered nano-plasmonic biosensing surface for colorimetric and SERS detection of DNA-hybridization events

机译:工程化的纳米等离子生物传感表面,用于比色和SERS检测DNA杂交事件

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摘要

We report a versatile nanophotonic biosensing platform that enables both colorimetric detection and enhanced Raman spectroscopy detection of molecular binding events. Through the integration of electron-beam lithography, dip-pen-nanolithography and molecular self-assembly, we demonstrate plasmonic nanostructures which change geometry and plasmonic properties in response to molecularly-mediated nanoparticle binding events. These biologically-active nanostructured surfaces hold considerable potential for use as multiplexed sensor platforms for point-of-care diagnostics, and as scaffolds for a new generation of molecularly dynamic metamaterials.
机译:我们报告了一个多功能的纳米光子生物传感平台,它能够进行比色检测和增强的拉曼光谱检测分子结合事件。通过电子束光刻,浸笔-纳米光刻和分子自组装的集成,我们证明了响应于分子介导的纳米粒子结合事件而改变几何形状和等离子体性质的等离子体纳米结构。这些具有生物活性的纳米结构表面具有巨大的潜力,可以用作即时诊断的多重传感器平台,以及用作新一代分子动力学超材料的支架。

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