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Ultracompact high-resolution photoacoustic microscopy of hemorrhagic shock

机译:失血性休克的超紧凑型高分辨率光声显微镜

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摘要

Hemorrhagic shock, as an important clinical issue, is regarding as a critical disease with a high mortality rate.Unfortunately, existing clinical technologies are inaccessible to assess the hemorrhagic shock via hemodynamics inmicrocirculation. Here, we proposed an ultracompact photoacoustic microscope to assess hemorrhagic shock by using arat model. In animal study, hemodynamic features of the microvascular network including concentration of totalhemoglobin (CHbT) and small vascular density (SVD) were derived to assess the microvascular hemodynamics ofdifferent organs, assessing the hemorrhagic shock via microcirculation. On the other hand, in vivo oral imaging ofhealthy volunteers also indicates the translational possibility of this technique for clinical evaluation of hemorrhagicshock.
机译:出血性休克作为重要的临床问题,被认为是具有高死亡率的关键疾病。\ r \ n遗憾的是,现有的临床技术无法通过微循环中的血流动力学评估出血性休克。在这里,我们提出了一种超紧凑型光声显微镜,通过使用a \ r \ nrat模型来评估失血性休克。在动物研究中,推导了微血管网络的血液动力学特征,包括总\ r \血红蛋白(CHbT)浓度和小血管密度(SVD),以评估\ n \ n不同器官的微血管血流动力学,通过微循环评估失血性休克。另一方面,健康志愿者的体内口腔成像也表明该技术可用于临床评估出血性休克的翻译可能性。

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  • 来源
    《Photons Plus Ultrasound: Imaging and Sensing 2019》|2019年|108782Z.1-108782Z.6|共6页
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  • 作者

    Qian Chen; Lei Xi;

  • 作者单位

    Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong,518055, China;

    Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong,518055, China xilei@sustc.edu.cn;

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