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首页> 外文会议>Polymers for biomedical applications >Novel Two-Photon Activated Photodynamic Therapy Agents: Design, Synthesis, and Preclinical Studies on Subcutaneous Cancerous Tumors
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Novel Two-Photon Activated Photodynamic Therapy Agents: Design, Synthesis, and Preclinical Studies on Subcutaneous Cancerous Tumors

机译：新型的两光子活化光动力治疗剂：皮下癌性肿瘤的设计，合成和临床前研究

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摘要

A new highly innovative two photon activated photodynamic therapy (PDT) triad agent has been synthesized successfully, which incorporates three different functional moieties: (1) photosensitizer: a porphyrin that has been substituted on the meso positions by chromophores with large two-photon absorption and activated in the NIR in the tissue transparency window and efficiently producing singlet oxygen as the cytotoxic agent; (2) a small molecule targeting agent that can target over-expressed receptor sites on the tumor, and (3) a NIR imaging agent that can accurately image the tumor for treatment. We have also been able to successfully transfect luciferase genes into model human tumor cell lines (both breast and lung cancers) that allows visualization of the efficacy of the two-photon PDT process.
机译：已经成功合成了一种高度创新的新型两光子活化光动力疗法（PDT）三合一剂，它结合了三个不同的功能部分：（1）光敏剂：一种卟啉，在卟啉的介孔位置上被具有大的两光子吸收和在组织透明窗口的NIR中激活，并有效产生单线态氧作为细胞毒剂； （2）小分子靶向剂，可靶向肿瘤上过度表达的受体位点；（3）NIR显像剂，可准确地对肿瘤成像以进行治疗。我们还能够成功地将萤光素酶基因转染到模型人类肿瘤细胞系（乳腺癌和肺癌）中，从而可视化双光子PDT过程的功效。

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