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首页> 外文会议>Proceedings of the 17th IASTED international conference on robotics applications ; Proceedings of the 11th IASTED international conference on biomedical engineering >ASSOCIATION OF FLOW-MEDIATED DILATION WITH SHEAR RATE IN PATIENTS AND HEALTHY VOLUNTEERS
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ASSOCIATION OF FLOW-MEDIATED DILATION WITH SHEAR RATE IN PATIENTS AND HEALTHY VOLUNTEERS

机译：患者和健康志愿者的流率稀释与剪切速率的关系

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Introduction: Flow mediated-dilation (FMD) is a non-invasive test of endothelial function based on shear stress-dependent nitric oxide secretion causing vasodilation. Normalization of FMD to shear stress was previously proposed. The aim of present study is an examination of relationship between shear rate and FMD in patients with hypertension and atherosclerosis in comparison with healthy volunteers. Methods: Three groups (11 with essential hypertension, 28 with advanced atherosclerosis and 26 controls) were examined. Flow mediated dilation after 5-minute cuff occlusion and post-deflation shear rate were assessed. Brachial artery diameters and blood velocities were obtained by means of high-resolution ultrasound machine. Results: Positive correlations were found between FMD and shear rate with correlation coefficients depending on the disease. Statistical significance was found in atherosclerosis and control groups. Shear rate stimulus is most effective in healthy controls and least effective in hypertensive patients. Conclusions: Post-ischemic shear rate or shear stress should also be taken into account while evaluating the endothelial function with vasodilation measurements.
机译：简介：血流介导的扩张（FMD）是基于剪切应力依赖性一氧化氮分泌引起血管扩张的内皮功能的非侵入性测试。以前建议将FMD标准化为剪应力。本研究的目的是与健康志愿者相比，检查高血压和动脉粥样硬化患者的剪切率与口蹄疫之间的关系。方法：检查三组（原发性高血压11例，晚期动脉粥样硬化28例和对照组26例）。评估5分钟袖带阻塞后的血流介导的扩张和放气后的剪切速率。肱动脉直径和血流速度通过高分辨率超声仪获得。结果：FMD与剪切速率之间存在正相关，相关系数取决于疾病。在动脉粥样硬化和对照组中发现统计学意义。剪切速率刺激在健康对照组中最有效，而在高血压患者中最不起作用。结论：在通过血管舒张测量评估内皮功能时，还应考虑缺血后的剪切速率或剪切应力。

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